Mice homozygous for the mutant autosomal recessive gene scid which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.

Annotation

NIM with no qualifiers when experimental animal

DUI

D016513 MeSH Browser

CUI

M0025206

Previous indexing

Mice, Mutant Strains (1983-1991)

History note

92

Public note

92