BACKGROUND: Squamous cell carcinoma of the head and neck is characterized by local invasiveness and metastases to regional lymph nodes. In 60% of cases, these tumours are dia-gnosed at an advanced stage, and the prognosis is unfavorable. One of the important factors of local, hematogenous or lymphogenic spread of the tumour in the human body is tumour cells migration ability. Advanced microscopic methods provide a new perspective on cell migration. PURPOSE: This paper presents a coherence controlled holographic microscopy method that provides a non-invasive quantitative evaluation of morphological and dynamic properties of living tumour cells. In connection with this method, new potential bio-markers are emerging, the significance of which, however, needs to be verified by correlation with clinical data.

• Klíčová slova
• Cell migration, epithelial-mesenchymal transition, head and neck carcinoma, coherence-controlled holographic microscopy, squamous cell carcinoma, tumor biomarkers, tumor markers,
• MeSH
• biologické markery MeSH
• dlaždicobuněčné karcinomy hlavy a krku MeSH
• lidé MeSH
• mikroskopie MeSH
• nádory hlavy a krku * diagnostické zobrazování   MeSH
• prognóza MeSH
• spinocelulární karcinom * diagnostické zobrazování   patologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• biologické markery MeSH

Trichorrhexis nodosa, i. e. a hair fracturing into brush-like widened stumps, was analyzed in an imbecile 4 year-old boy without any sign of aminoaciduria or disturbance of copper metabolism. Scanning electron microscopy showed smoothed hair cuticula with irregular ridges and surface splitting. According to the transmission electron microscopy disintegration of superficial and profound cuticular elements as well was due to progressive development of vacuoles and clefts in amorphous keratin.

• MeSH
• lidé MeSH
• nemoci vlasů patologie   MeSH
• předškolní dítě MeSH
• vlasy, chlupy patologie   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• předškolní dítě MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• kazuistiky MeSH

• MeSH
• estery cholesterolu metabolismus   MeSH
• lidé MeSH
• mladiství MeSH
• vrozené poruchy metabolismu tuků * diagnóza   MeSH
• Check Tag
• lidé MeSH
• mladiství MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• estery cholesterolu MeSH

The ECG characters were studied in two sires (Manrico and Infernal) and their 26-membered set of progeny as well as in one mare (Victoire) and her five daughters. The confer of some ECG characters from the sire's side as well as from the mare's side to the offspring was demonstrated. The consistency of some ECG characters was particularly obvious in externally dominant Manrico sire and his offspring as well as in the breeding mare and her five daughters (inclination of the electric cardiac axis, intrinsicoid deflexion lag, P wave shape, deep S in the 3rd connection).

• MeSH
• elektrokardiografie veterinární   MeSH
• koně genetika   fyziologie   MeSH
• zvířata MeSH
• Check Tag
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH

• MeSH
• amylasy krev   MeSH
• dítě MeSH
• lidé MeSH
• molekulová hmotnost MeSH
• předškolní dítě MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mužské pohlaví MeSH
• předškolní dítě MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• amylasy MeSH

• MeSH
• adenom z ostrůvkových buněk komplikace   MeSH
• dítě MeSH
• hypoglykemie komplikace   MeSH
• kojenec MeSH
• lidé MeSH
• mladiství MeSH
• nádory slinivky břišní komplikace   MeSH
• předškolní dítě MeSH
• záchvaty diagnóza   etiologie   MeSH
• Check Tag
• dítě MeSH
• kojenec MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• předškolní dítě MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• kazuistiky MeSH

In 246 horses of the English Thoroughbred breed of several age categories, divided into four test populations, the influence was studied of age and training on the pulse rate and time intervals of ECG (PQ, QRS, QT and QTc). It was found that with the increasing age and training action slowed down gradually. Duration of the atrioventricular path (PQ) is prolonged, time of ventricular activation (QRS) and time of the electrical systole (QT) including its value corrected according to the actual pulse rate (QTC). In this way the origin of the so called sports electrocardiogram in trained race horses is characterized.

• MeSH
• elektrokardiografie veterinární   MeSH
• kondiční příprava zvířat * MeSH
• koně fyziologie   MeSH
• stárnutí * MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH

• MeSH
• dítě MeSH
• kožní nemoci diagnóza   MeSH
• lidé MeSH
• nemoci jater diagnóza   MeSH
• porfyrie diagnóza   MeSH
• věkové faktory MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• kazuistiky MeSH

Sixty seven thoroughbred race horse of various age categories were examined electrocardiographically by bipolar leak-apex of the heart -- withers; length of training corresponded to the age categories. Basic time and voltage criteria of EKG were statistically evaluated according to electrocardiographic curves: TF = 35.1 = %/- 6.82 pulses per min., time P = 0.16 +/- 0.03 sec., PQ = 0.03 +/- 0.04 sec., QRS = 0.12 +/- +/- 0.01 sec., TQc = 0.50 sec., R = 2.83 +/- 0.63 mV, Q = 0.38 +/- 0.31 mV. Repolarization phase of the chamber complex, mainly the T wave, is the most variable component of the whole EKG. In the set under study AV block I was found in 14.93%, AV block II in 2.98%, sinoauricular block II in 1.49% and auricular fibrillation in 1.49%. In the paper the basic EKG values and occurrence of arrhythmia in relation to the rate of the training of horses are discussed.

• MeSH
• elektrokardiografie * MeSH
• koně MeSH
• nemoci koní diagnóza   MeSH
• sporty MeSH
• srdeční arytmie diagnóza   veterinární   MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH

Surface electric potentials of the heart of four horses were measured by use of unipolar leak with the so called central Wilson's clip; the measurements were performed on 95 precisely fixed places of the equine body. Potentials found out in this way were re-measured with bipolar leaks: the negative electrode was fixed in the place of the highest negative potentials, the positive electrode was gradually attached to places with the highest values of positive potentials. The largest potential differences when the negative electrode was placed in the region of the heart were obtained from the region of the withers, spinal and scapular regions, from forehead and nose. On the basis of these potential differences the most suitable places for uni-leak bipolar electrocardiography and radiotelemetric registration of EKG were selected. Bipolar leak -- apex of the heart -- withers -- appears most suitable; it provides the best potential and time reproducibility of EKG. The results have been processed statistically and arranged graphically.

• MeSH
• akční potenciály * MeSH
• koně fyziologie   MeSH
• lidé MeSH
• srdce fyziologie   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH