Dromedaries are an important livestock, used as beasts of burden and for meat and milk production. However, they can act as an intermediate source or vector for transmitting zoonotic viruses to humans, such as the Middle East respiratory syndrome coronavirus (MERS-CoV) or Crimean-Congo hemorrhagic fever virus (CCHFV). After several outbreaks of CCHFV in the Arabian Peninsula, recent studies have demonstrated that CCHFV is endemic in dromedaries and camel ticks in the United Arab Emirates (UAE). There is no apparent disease in dromedaries after the bite of infected ticks; in contrast, fever, myalgia, lymphadenopathy, and petechial hemorrhaging are common symptoms in humans, with a case fatality ratio of up to 40%. We used the in-solution hybridization capture of 100 annotated immune genes to genotype 121 dromedaries from the UAE tested for seropositivity to CCHFV. Through univariate linear regression analysis, we identified two candidate genes belonging to the innate immune system: FCAR and CLEC2B. These genes have important functions in the host defense against viral infections and in stimulating natural killer cells, respectively. This study opens doors for future research into immune defense mechanisms in an enzootic host against an important zoonotic disease.
- Klíčová slova
- Camelus dromedarius, Old World camel, in-solution hybridization capture, tick, vector-borne infection, zoonosis,
- MeSH
- genetická predispozice k nemoci genetika MeSH
- genotyp MeSH
- hemoragická horečka krymská genetika imunologie virologie MeSH
- infestace klíšťaty imunologie parazitologie MeSH
- klíšťata imunologie fyziologie virologie MeSH
- koronavirové infekce genetika imunologie virologie MeSH
- kuřecí embryo MeSH
- lidé MeSH
- odolnost vůči nemocem genetika imunologie MeSH
- přirozená imunita genetika imunologie MeSH
- rizikové faktory MeSH
- velbloudi genetika imunologie virologie MeSH
- virus krymsko-konžské hemoragické horečky imunologie fyziologie MeSH
- zoonózy genetika imunologie virologie MeSH
- zvířata MeSH
- Check Tag
- kuřecí embryo MeSH
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Spojené arabské emiráty MeSH
