Brain activity during the resting state is widely used to examine brain organization, cognition and alterations in disease states. While it is known that neuromodulation and the state of alertness impact resting-state activity, neural mechanisms behind such modulation of resting-state activity are unknown. In this work, we used a computational model to demonstrate that change in excitability and recurrent connections, due to cholinergic modulation, impacts resting-state activity. The results of such modulation in the model match closely with experimental work on direct cholinergic modulation of Default Mode Network (DMN) in rodents. We further extended our study to the human connectome derived from diffusion-weighted MRI. In human resting-state simulations, an increase in cholinergic input resulted in a brain-wide reduction of functional connectivity. Furthermore, selective cholinergic modulation of DMN closely captured experimentally observed transitions between the baseline resting state and states with suppressed DMN fluctuations associated with attention to external tasks. Our study thus provides insight into potential neural mechanisms for the effects of cholinergic neuromodulation on resting-state activity and its dynamics.
- MeSH
- acetylcholin metabolismus MeSH
- default mode network fyziologie diagnostické zobrazování MeSH
- dospělí MeSH
- konektom * MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- modely neurologické * MeSH
- mozek * fyziologie diagnostické zobrazování MeSH
- nervová síť fyziologie diagnostické zobrazování MeSH
- odpočinek * fyziologie MeSH
- počítačová simulace MeSH
- výpočetní biologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- acetylcholin MeSH
