Nitric oxide (NO) is implicated in a wide variety of biological roles. NO is generated from three nitric oxide synthase (NOS) isoforms: neuronal (nNOS), inducible (iNOS), and endothelial (eNOS) all of which are found in the lung. While there are no isoform-specific inhibitors of NOS, the recent development and characterization of mice deficient in each of the NOS isoforms has allowed for more comprehensive study of the importance of NO in the lung circulation. Studies in the mouse have identified the role of NO from eNOS in modulating pulmonary vascular tone and in attenuating the development of chronic hypoxic pulmonary hypertension.

• MeSH
• cévy patofyziologie   MeSH
• myši knockoutované MeSH
• myši MeSH
• plicní hypertenze etiologie   patofyziologie   MeSH
• plicní oběh MeSH
• synthasa oxidu dusnatého fyziologie   MeSH
• vazomotorický systém fyziologie   MeSH
• zvířata MeSH
• Check Tag
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• synthasa oxidu dusnatého MeSH