The field of mRNA translation has witnessed an impressive expansion in the last decade. The once standard model of translation initiation has undergone, and is still undergoing, a major overhaul, partly due to more recent technical advancements detailing, for example, initiation at non-AUG codons. However, some of the pioneering works in this area have come from immunology and more precisely from the field of antigen presentation to the major histocompatibility class I (MHC-I) pathway. Despite early innovative studies from the lab of Nilabh Shastri demonstrating alternative mRNA translation initiation as a source for MHC-I peptide substrates, the mRNA translation field did not include these into their models. It was not until the introduction of the ribo-sequence technique that the extent of non-canonical translation initiation became widely acknowledged. The detection of peptides on MHC-I molecules by CD8 + T cells is extremely sensitive, making this a superior model system for studying alternative mRNA translation initiation from specific mRNAs. In view of this, we give a brief history on alternative initiation from an immunology perspective and its fundamental role in allowing the immune system to distinguish self from non-self and at the same time pay tribute to the works of Nilabh Shastri.
- Klíčová slova
- Antigen presentation, MHC class I pathway, mRNA translation initiation,
- MeSH
- CD8-pozitivní T-lymfocyty imunologie MeSH
- lidé MeSH
- messenger RNA genetika imunologie MeSH
- MHC antigeny I. třídy genetika imunologie MeSH
- peptidy genetika imunologie MeSH
- prezentace antigenu genetika imunologie MeSH
- proteosyntéza genetika imunologie MeSH
- receptory pro aktivovanou kinasu C genetika imunologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- messenger RNA MeSH
- MHC antigeny I. třídy MeSH
- peptide I MeSH Prohlížeč
- peptidy MeSH
- receptory pro aktivovanou kinasu C MeSH
