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Článek

Striking Effect of Polymer End-Group on C60 Nanoparticle Formation by High Shear Vibrational Milling with Alkyne-Functionalized Poly(2-oxazoline)s

Van Guyse, Joachim F R
Autor Van Guyse, Joachim F R Supramolecular Chemistry Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4, 9000 Ghent, Belgium
de la Rosa, Victor R
Autor de la Rosa, Victor R Supramolecular Chemistry Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4, 9000 Ghent, Belgium
Lund, Reidar
Autor Lund, Reidar ORCID Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, 0371 Oslo, Norway
De Bruyne, Michiel
Autor De Bruyne, Michiel Ghent University, Department of Biomedical Molecular Biology, 9052 Ghent, Belgium and VIB Center for Inflammation Research, 9052 Ghent, Belgium Ghent University Expertise Centre for Transmission Electron Microscopy and VIB BioImaging Core, 9052 Ghent, Belgium
De Rycke, Riet
Autor De Rycke, Riet Ghent University, Department of Biomedical Molecular Biology, 9052 Ghent, Belgium and VIB Center for Inflammation Research, 9052 Ghent, Belgium Ghent University Expertise Centre for Transmission Electron Microscopy and VIB BioImaging Core, 9052 Ghent, Belgium
Filippov, Sergey K
Autor Filippov, Sergey K ORCID Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského nám. 2, 162 06 Prague 6, Czech Republic
Hoogenboom, Richard
Autor Hoogenboom, Richard ORCID Supramolecular Chemistry Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4, 9000 Ghent, Belgium

ACS macro letters. 2019 Feb 19 ; 8 (2) : 172-176. [epub] 20190123

ACS Macro Lett
ISSN 2161-1653
Zdroj

Buckminsterfullerene (C60) has a large potential for biomedical applications. However, the main challenge for the realization of its biomedical application potential is to overcome its extremely low water solubility. One approach is the coformulation with biocompatible water-soluble polymers, such as poly(2-oxazoline)s (PAOx), to form water-soluble C60 nanoparticles (NPs). However, uniform and defined NPs have only been obtained via a thin film hydration method or using cyclodextrin-functionalized PAOx. Here, we report the mechanochemical preparation of defined and stable C60:PAOx NPs by the introduction of a simple alkyne group as a polymer end-group. The presence of this alkyne bond is proven to be crucial in the mechanochemical synthesis of stable, defined sub-100 nm C60:PAOx NPs, with high C60 content up to 8.9 wt %.

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