To investigate the effect of light cue on the resetting of the peripheral clocks, we examined the resetting processes of clock genes (Per1, Per2, Bmal1, Cry1, Dec1, and Rev-erbalpha) in the liver and heart of rats after the feeding and light-dark (LD) reversal via a 24-h light period transition. The liver clock was reset quickly within 3 days, while the heart clock needed a longer time course of 5-7 days to be completely re-entrained. Moreover, the re-entrainment of Per1 and Per2 in the liver clock was more rapid than that of the other four clock genes, suggesting the important role of these two clock genes in initiating the circadian resetting of the hepatic clock. However, the resetting rates of these two clock genes were as similar as the others in the heart clock. Therefore, the resetting mechanisms underlining these two peripheral clocks may be totally distinct. Furthermore, the re-entrainment of the liver and heart clocks were relatively lengthened after the feeding and LD reversal via a light period transition compared to a dark period transition, suggesting a simultaneous shift of feeding schedule and the LD cycle may facilitate the circadian resetting in rats.
- MeSH
- biologické hodiny genetika MeSH
- cirkadiánní proteiny Period genetika MeSH
- cirkadiánní rytmus genetika MeSH
- fotoperioda * MeSH
- homeodoménové proteiny genetika MeSH
- jaderné receptory - podrodina 1, skupina D, člen 1 genetika MeSH
- játra metabolismus MeSH
- jet lag syndrom genetika patofyziologie MeSH
- kryptochromy genetika MeSH
- krysa rodu Rattus MeSH
- messenger RNA metabolismus MeSH
- myokard metabolismus MeSH
- podněty MeSH
- potkani Wistar MeSH
- regulace genové exprese MeSH
- stravovací zvyklosti * MeSH
- světelná stimulace MeSH
- transkripční faktory ARNTL genetika MeSH
- transkripční faktory bHLH genetika MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- Bhlhe40 protein, rat MeSH Prohlížeč
- cirkadiánní proteiny Period MeSH
- Cry1 protein, rat MeSH Prohlížeč
- homeodoménové proteiny MeSH
- jaderné receptory - podrodina 1, skupina D, člen 1 MeSH
- kryptochromy MeSH
- messenger RNA MeSH
- Nr1d1 protein, rat MeSH Prohlížeč
- Per1 protein, rat MeSH Prohlížeč
- Per2 protein, rat MeSH Prohlížeč
- transkripční faktory ARNTL MeSH
- transkripční faktory bHLH MeSH
