A case report of a 68-year-old otherwise-healthy female patient with Spetzler-Martin (SM) grade I arteriovenous malformation (AVM) in her left frontal region is presented. After an uneventful surgery, cerebral venous infarction developed, and the patient was rendered hemiparetic with motor aphasia. After bony decompression, slow improvement was seen, and 3 months after surgery, the patient was neurologically intact. Six months after AVM resection, cranioplasty was performed. Infarction was caused by the thrombosis of a long primary draining vein, which finished its course in the normal cortical venous system. The case supports the venous origin of postoperative bleeding after AVM resection instead of the normal perfusion pressure phenomenon.

• Klíčová slova
• Cerebral arteriovenous malformation, venous occlusive disease,
• MeSH
• cerebrální infarkt * etiologie   chirurgie   MeSH
• intrakraniální arteriovenózní malformace * chirurgie   komplikace   MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• mozkové žíly chirurgie   diagnostické zobrazování   MeSH
• pooperační komplikace etiologie   chirurgie   MeSH
• senioři MeSH
• Check Tag
• lidé MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

BACKGROUND: The central vein sign (CVS) has been proposed as a novel MRI biomarker to improve diagnosis of pediatric-onset MS (POMS). However, the role of CVS in POMS progression has yet to be discovered. OBJECTIVES: To investigate the appearance of CVS and its correlation with POMS disease progression. METHODS: One hundred fifty-six POMS from two MS centers in Israel and Czech Republic MS centers were followed for five years. Patient assessment was performed by the Expanded Disability Status Scale (EDSS) and Annual Relapse Rate (ARR). Patients in whom at least 40 % of brain MRI lesions had CVS ("rule of 40") were determined as CVS-positive. RESULTS: The total group of POMS consisted of 96 CVS-negative (61.5 %), aged 14.6 ± 1.9 years, EDSS 2.0, 75 % Interquartile Range (IQR) 1.0-3.0, disease duration (DD) 6.28 ± 0.38 years, and 60 CVS-positive (38.5 %), aged 15.1 ± 0.3 years, EDSS 2.0, IQR 1.5-3.0, DD 5.62 ± 0.13 years, were analyzed. After a three and five-year follow-up, the CVS-positive patients had higher EDSS scores than those who were CVS-negative, 2.0, IQR 1.0-2.5, vs 1.0, IQR 1.0-2.0, (p = 0.009) and 2.0, IQR 1.0-3.25 vs 1.0, IQR 1.0-2.0, (p = 0.0003), respectively. Patients with CVS-positive POMS were characterized by a significantly higher ARR (0.78 ± 0.08 vs 0.57 ± 0.04, p = 0.002). These results were confirmed in subgroups of Disease Modifying Treatments (DMT) untreated and treated patients. CONCLUSION: CVS-positive POMS is characterized by higher disability progression than CVS-negative, indicating the importance of CVS in disease pathogenesis.

• MeSH
• dítě MeSH
• lidé MeSH
• magnetická rezonanční tomografie * MeSH
• mladiství MeSH
• mozek diagnostické zobrazování   patologie   MeSH
• mozkové žíly diagnostické zobrazování   patofyziologie   MeSH
• následné studie MeSH
• posuzování pracovní neschopnosti MeSH
• progrese nemoci * MeSH
• roztroušená skleróza diagnostické zobrazování   patofyziologie   MeSH
• věk při počátku nemoci MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• Geografické názvy
• Česká republika MeSH
• Izrael MeSH

AIMS: The transcondylar approach is a new and used for detection of chronic cerebro-spinal venous insufficiency (CCSVI) and intracranial venous reflux in patients with multiple sclerosis. The aim of this study was to assess the ability of native and contrast enhanced (CE-) transcranial color-coded duplex sonography (TCCS) to detect flow and reflux in deep cerebral veins and intracranial venous sinuses from transcondylar and transtemporal approaches. METHODS: Brain magnetic resonance imaging and TCCS from transtemporal and transcondylar approaches using the new technology - Fusion Imaging - in 8 volunteers and 5 patients with multiple sclerosis. RESULTS: Using TCCS and CE-TCCS, the arteries of the circle of Willis could be detected from the transtemporal approach in 13/13 subjects in both examinations, while detection of the venous system was possible in 7/13 and 9/13 subjects, respectively. However, the arteries of the circle of Willis and venous system were detected through the transcondylar approach in only 5/13 (P=0.041) and 1/13 (P=0.031) subjects using TCCS, and in 12/13 (P=0.921) and 7/13 (P=0.687) subjects using CE-TCCS, respectively. CONCLUSIONS: The results reveal that the TCCS transcondylar approach has serious limitations for the standard detection of intracranial venous reflux.

• Klíčová slova
• Virtual Navigator, fusion imaging, magnetic resonance imaging, reflux, ultrasound, venous system,
• MeSH
• arteriae cerebrales diagnostické zobrazování   MeSH
• chronická nemoc MeSH
• dospělí MeSH
• kontrastní látky MeSH
• lidé středního věku MeSH
• lidé MeSH
• magnetická rezonanční angiografie MeSH
• mozkové žíly diagnostické zobrazování   MeSH
• mozkový krevní oběh fyziologie   MeSH
• roztroušená skleróza diagnostické zobrazování   MeSH
• sinus durae matris diagnostické zobrazování   MeSH
• ultrasonografie dopplerovská barevná metody   MeSH
• ultrasonografie dopplerovská transkraniální metody   MeSH
• zdraví dobrovolníci pro lékařské studie MeSH
• žilní insuficience diagnostické zobrazování   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• hodnotící studie MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH
• Názvy látek
• kontrastní látky MeSH

The aim of the investigation was to reveal the existence of venous angiomas of the brain by serioangiography in selected neurological diseases and to test the possible connection between the angiographic finding of a VA and neurological symptomatology. The material was formed by 386 serioangiograms in patients with subarachnoid haemorrhage, intracerebral haemorrhage, focal epilepsy and unilateral headache. It was revealed that from the total number of mentioned diagnoses there were 18 venous angiomas, i.e. 4.66%. Intracerebral haemorrhage and unilateral headache were most frequent (7.3% and 9%). No difference was found between the right and left hemisphere and between different brain areas. Cerebral angiography remains an important method in the diagnosis of venous angiomas of the brain, provided a satisfactory programme and high quality material are used. Examination by computed tomography without a contrast is of little diagnostic value, the use of contrast in computer tomography can improve the diagnosis.

• MeSH
• cerebrální krvácení etiologie   MeSH
• hemangiom komplikace   diagnostické zobrazování   MeSH
• lidé MeSH
• mozková angiografie * MeSH
• mozkové žíly * diagnostické zobrazování   MeSH
• nádory mozku komplikace   diagnostické zobrazování   MeSH
• retrospektivní studie MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

• MeSH
• intrakraniální arteriovenózní malformace * diagnostické zobrazování   patologie   MeSH
• kojenec MeSH
• lidé MeSH
• mozkové žíly abnormality   diagnostické zobrazování   patologie   MeSH
• radiografie MeSH
• Check Tag
• kojenec MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH