Omega-3 fatty acids (omega3FA) are known to reduce hypertriglyceridemia- and inflammation-induced vascular wall diseases. However, mechanisms of their effects are not completely clear. We examined, whether 10-day omega3FA diet can reduce bacterial lipopolysaccharide-induced changes in expression of gap junction protein connexin40 (Cx40) in the aorta of hereditary hypertriglyceridemic (hHTG) rats. After administration of a single dose of lipopolysaccharide (LPS, 1 mg/kg, i.p.) to adult hHTG rats, animals were fed with omega3FA diet (30 mg/kg/day) for 10 days. LPS decreased Cx40 expression that was associated with reduced acetylcholine-induced relaxation of aorta. Omega3FA administration to LPS rats had partial anti-inflammatory effects, associated with increased Cx40 expression and improved endothelium dependent relaxation of the aorta. Our results suggest that 10-day omega3FA diet could protect endothelium-dependent relaxation of the aorta of hHTG rats against LPS-induced damage through the modulation of endothelial Cx40 expression.
- MeSH
- antigeny diferenciační myelomonocytární metabolismus MeSH
- aorta účinky léků metabolismus MeSH
- CD antigeny metabolismus MeSH
- hypertriglyceridemie vrozené dietoterapie metabolismus MeSH
- konexiny metabolismus MeSH
- krysa rodu Rattus MeSH
- lipopolysacharidy MeSH
- omega-3 mastné kyseliny farmakologie terapeutické užití MeSH
- protein alfa 5 mezerového spoje MeSH
- western blotting MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antigeny diferenciační myelomonocytární MeSH
- CD antigeny MeSH
- CD68 protein, rat MeSH Prohlížeč
- konexiny MeSH
- lipopolysacharidy MeSH
- omega-3 mastné kyseliny MeSH
