The pathogenicity of B. abortus 870 L-forms obtained by long-term passaging of virulent culture on media with penicillin and of revertants obtained in vitro and in vivo was studied. L-form cultures stimulated only a mild response of the reticulo-endothelial system of the animal organism, at the same time displaying a certain level of toxicity. In vitro revertants approximated to L-forms, while in vivo revertants stood closer to the initial virulent culture, as regards pathogenicity. This seems to be evidence of a potential danger of brucella L-forms for the human and animal organisms.

• MeSH
• Brucella abortus růst a vývoj   imunologie   patogenita   MeSH
• brucelóza imunologie   mikrobiologie   MeSH
• druhová specificita MeSH
• hemaglutininy analýza   MeSH
• kultivační média MeSH
• L-formy bakterií imunologie   patogenita   MeSH
• morčata MeSH
• peniciliny farmakologie   MeSH
• virulence MeSH
• zvířata MeSH
• Check Tag
• morčata MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• hemaglutininy MeSH
• kultivační média MeSH
• peniciliny MeSH