The fast-track process to approve vaccines against COVID-19 has raised questions about their safety, especially in relation to fertility. Over the last 2 years, studies have appeared monitoring female fertility, especially from assisted reproduction centers or in animal experiments. However, studies monitoring healthy populations are still limited. The aim of our study was to monitor the relevant parameters of female fertility (sex and other steroids, LH, FSH, SHBG, Antimüllerian hormone and antral follicle count) before and then 2-4 months after the third dose of vaccination against COVID-19 in a group of 25 healthy fertile woman. In addition, anti-SARS-CoV-2 and anti-SARS-CoV-2S antibodies were determined. We did not observe significant changes in the measured parameters before and after the third dose of vaccination. By comparing levels of the analytes with antibodies indicating a prior COVID-19 infection, we found that women who had experienced the disease had statistically lower levels of estrone, estradiol, SHBG and 5α-dihydroprogesterone, and conversely, higher levels of androgen active dehydroepiandrosterone and dihydrotestosterone. Our results confirm that vaccination does not affect female fertility, and that what fertile women should be worried about is not vaccination, but rather COVID-19 infection itself.

• Klíčová slova
• AMH, COVID-19, antral follicle count, infection, safety, steroids, vaccination, woman fertility,
• MeSH
• 20-alfa-dihydroprogesteron MeSH
• androgeny MeSH
• antimülleriánský hormon * MeSH
• COVID-19 * prevence a kontrola   MeSH
• dehydroepiandrosteron MeSH
• dihydrotestosteron MeSH
• estradiol MeSH
• estron MeSH
• fertilita MeSH
• folikuly stimulující hormon MeSH
• lidé MeSH
• vakcíny proti COVID-19 MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH
• Názvy látek
• 20-alfa-dihydroprogesteron MeSH
• androgeny MeSH
• antimülleriánský hormon * MeSH
• dehydroepiandrosteron MeSH
• dihydrotestosteron MeSH
• estradiol MeSH
• estron MeSH
• folikuly stimulující hormon MeSH
• vakcíny proti COVID-19 MeSH

Progesterone is a steroid hormone traditionally linked with female fertility and pregnancy. In current reproductive medicine, progesterone and its analogues play crucial roles. While the discovery of its effects has a long history, over recent decades, various novel actions of this interesting steroid have been documented, of which its neuro- and immunoprotective activities are the most widely discussed. Discoveries of the novel biological activities of progesterone have also driven research and development in the field of progesterone analogues used in human medicine. Progestogen treatment has traditionally and predominately been used in maintaining pregnancy, the prevention of preterm labor, various gynecological pathologies, and in lowering the negative effects of menopause. However, there are also various other medical fields where progesterone and its analogues could find application in the future. The aim of this work is to show the mechanisms of action of progesterone and its metabolites, the physiological and pharmacological actions of progesterone and its synthetic analogues in human medicine, as well as the impacts of its production and use on the environment.

• Klíčová slova
• CNS disorder, endocrine disruption, gynecology, menopause, miscarriage, neurosteroid, pregnancy, preterm birth, progestagen, progesterone, progestin, progestogen,
• MeSH
• hormony MeSH
• lidé MeSH
• novorozenec MeSH
• progesteron * farmakologie   fyziologie   MeSH
• progestiny * farmakologie   terapeutické užití   MeSH
• těhotenství MeSH
• Check Tag
• lidé MeSH
• novorozenec MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• hormony MeSH
• progesteron * MeSH
• progestiny * MeSH