The development of acute respiratory distress syndrome (ARDS) is known to be independently attributable to aspiration-induced lung injury. Mechanical ventilation as a high pressure/volume support to maintain sufficient oxygenation of a patient could initiate ventilator-induced lung injury (VILI) and thus contribute to lung damage. Although these phenomena are rare in the clinic, they could serve as the severe experimental model of alveolar-capillary membrane deterioration. Lung collapse, diffuse inflammation, alveolar epithelial and endothelial damage, leakage of fluid into the alveoli, and subsequent inactivation of pulmonary surfactant, leading to respiratory failure. Therefore, exogenous surfactant could be considered as a therapy to restore lung function in experimental ARDS. This study aimed to investigate the effect of modified porcine surfactant in animal model of severe ARDS (P/F ratio

• MeSH
• edém MeSH
• králíci MeSH
• kyselina chlorovodíková toxicita   terapeutické užití   MeSH
• plíce MeSH
• plicní surfaktanty * terapeutické užití   farmakologie   MeSH
• poškození plic mechanickou ventilací * farmakoterapie   MeSH
• povrchově aktivní látky farmakologie   terapeutické užití   MeSH
• prasata MeSH
• syndrom dechové tísně * chemicky indukované   farmakoterapie   MeSH
• zánět MeSH
• zvířata MeSH
• Check Tag
• králíci MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• kyselina chlorovodíková MeSH
• plicní surfaktanty * MeSH
• povrchově aktivní látky MeSH