The immunomodulatory activities of monophosphoryl lipid A (MLA) and diphosphoryl lipid A analogues obtained from the sensitive strain of E. coli and from the resistant strains adapted to a quaternary ammonium salt and an amine oxide were compared. All analogues considerably stimulated the activity of human leukocytes although the analogue from the sensitive strain at a higher concentration significantly suppressed phagocytosis. The MLA analogue exhibited a suppressive effect on the microbicidal activity of human leukocytes against E. coli and the peroxidase activity. Adaptation of bacteria to amphiphilic antimicrobial compounds, which is accompanied by chemical changes in their lipid A, only slightly reduced their immunomodulatory activity when compared with the analogue from the sensitive strain. On the other hand, the diphosphoryl analogues were less active than MLA.

• MeSH
• bakteriální léková rezistence MeSH
• dimethylaminy farmakologie   MeSH
• Escherichia coli účinky léků   imunologie   fyziologie   MeSH
• fagocytóza MeSH
• kvartérní amoniové sloučeniny farmakologie   MeSH
• leukocyty enzymologie   imunologie   metabolismus   MeSH
• lidé MeSH
• lipid A analogy a deriváty   imunologie   MeSH
• muramidasa metabolismus   MeSH
• peroxidasa metabolismus   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH
• Názvy látek
• dimethylaminy MeSH
• diphosphoryl lipid A MeSH Prohlížeč
• kvartérní amoniové sloučeniny MeSH
• lipid A MeSH
• monophosphoryl lipid A MeSH Prohlížeč
• muramidasa MeSH
• N-(1-methyldodecyl)-N,N,N-trimethylammonium MeSH Prohlížeč
• N,N-dimethyl-1-methyldodecylamine oxide MeSH Prohlížeč
• peroxidasa MeSH