Among 31 3,4-dihydro-s-triazinobenzimidazole derivatives tested 12 compounds showed in vitro antimicrobial activity against G+ bacteria. Best results were obtained with substances containing naphthyl or halogenated phenyl group on the triazine ring. The tested derivatives had no significant in vitro antimicrobial activity against either the used G- species or fungi.

• MeSH
• Anti-Bacterial Agents MeSH
• Anti-Infective Agents chemistry   pharmacology   MeSH
• Benzimidazoles chemistry   pharmacology   MeSH
• Gram-Negative Bacteria drug effects   MeSH
• Gram-Positive Bacteria drug effects   MeSH
• Fungi drug effects   MeSH
• Microbial Sensitivity Tests MeSH
• Triazines chemistry   MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH
• Anti-Infective Agents MeSH
• Benzimidazoles MeSH
• Triazines MeSH

Antifungal activity of new copper(II) complexes of 2-methylthionicotinate (2-MeSNic) of the composition Cu(2-MeSNic)2(MeNia)(2).4H2O (where MeNia is N-methylnicotinamide), and Cu(2-MeSNic)2(Nia)(2).2H2O (where Nia is nicotinamide) and Cu(2-MeSNic)2L2 (where L is isonicotinamide, iNia, or ethyl nicotinate, EtNic) were tested on various strains of filamentous fungi by the macrodilution method. Most sensitive against copper(II) adducts with bioactive ligands were Rhizopus oryzae and Microsporum gypseum (IC50 1.5-2.3 mmol/L). The adducts with Nia, MeNia and EtNic at 5 mmol/L induced morphological changes in growing hyphae of Botrytis cinerea, mainly their intensive branching attached to release of cytoplasm with partial growth inhibition. Inhibition of sporulation (> 90%) of Alternaria alternata by Cu(2-MeSNic)2.H2O was observed as a change in the color of the colonies. The highest resistance was marked by B. cinerea and Fusarium moniliforme (average IC50 values 4.25 and 3.13 mmol/L, respectively). The presence of all bioactive ligands in copper(II) complexes caused an increase in the inhibition effect against model fungi (except significant inhibition activity of EtNic on R. oryzae).

• MeSH
• Alternaria drug effects   MeSH
• Antifungal Agents chemistry   pharmacology   MeSH
• Fusarium drug effects   MeSH
• Copper chemistry   pharmacology   MeSH
• Microbial Sensitivity Tests MeSH
• Organometallic Compounds pharmacology   MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Antifungal Agents MeSH
• Copper MeSH
• Organometallic Compounds MeSH

The antifungal activity of fourteen novel derivatives of oxindole with side chain was studied using representatives of toxinogenic, phytopathogenic and dermatophytic filamentous fungi. Derivatives with exocyclic C=C bond in position C-3 exhibited a higher antifungal activity compared with derivatives with an exocyclic C-C bond in the same position. The strongest antifungal effects were shown by 3-(-2-thienoylmethylidene)-indol-2(3H)-ones.

• MeSH
• Antifungal Agents pharmacology   MeSH
• Aspergillus flavus drug effects   MeSH
• Botrytis drug effects   MeSH
• Fusarium drug effects   MeSH
• Indoles metabolism   pharmacology   MeSH
• Microsporum drug effects   MeSH
• Microbial Sensitivity Tests MeSH
• Oxidation-Reduction MeSH
• Penicillium metabolism   MeSH
• Antineoplastic Agents pharmacology   MeSH
• Rhizopus drug effects   MeSH
• Mutagenicity Tests MeSH
• Trichophyton drug effects   MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Antifungal Agents MeSH
• Indoles MeSH
• Antineoplastic Agents MeSH