We studied the effect of food restriction, overfeeding, and normofeeding on cachexia, inflammatory and metabolic parameters, and insulin sensitivity in chronic adjuvant arthritis (AA) in rats. Food restriction during AA increased circulating ghrelin, corticosterone, decreased leptin, and ameliorated arthrogram score and systemic inflammation compared to normofeeding. Overfeeding worsened arthrogram score and systemic inflammation, and led to lipid accumulation in the liver, but not to alterations of adipokine and ghrelin plasma levels relative to normofeeding. Independently of feeding status, AA induced cachexia, in which modulation of mRNA expressions for appetite-regulating neuropeptides (NPY, AgRP, POMC, CART) in the arcuate nucleus (ARC) does not play a primary role. The overexpression of IL-1β mRNA in the ARC suggests its role in the mechanisms of impaired energy balance during AA under all feeding conditions. Normal HOMA index in all arthritic groups does not indicate the development of insulin resistance by feeding interventions in these rats.

• MeSH
• Adipokines metabolism   MeSH
• Chemotherapy, Adjuvant methods   MeSH
• Arthritis diet therapy   therapy   MeSH
• Ghrelin metabolism   MeSH
• Adrenal Cortex Hormones metabolism   MeSH
• Insulin metabolism   MeSH
• Cachexia metabolism   MeSH
• Animal Feed * MeSH
• Rats MeSH
• Leptin metabolism   MeSH
• Neuropeptides chemistry   MeSH
• Arcuate Nucleus of Hypothalamus metabolism   MeSH
• Rats, Inbred Lew MeSH
• Inflammation MeSH
• Animals MeSH
• Check Tag
• Rats MeSH
• Male MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Adipokines MeSH
• Ghrelin MeSH
• Adrenal Cortex Hormones MeSH
• Insulin MeSH
• Leptin MeSH
• Neuropeptides MeSH