The specificity of three commonly used inhibitors of DNA synthesis were tested in the batch culture of Streptococcus faecalis ATCC 8043 in rich broth medium. It was shown that nalidixic acid, mitomycin C and 6-(4-hydroxyphenylazo)uracil inhibit the growth of the cell mass as much as they decrease net DNA synthesis. Hence the drugs tested are highly unspecific inhibitors of DNA synthesis in S. faecalis; i.e. they all interfere with other processes as well as with DNA synthesis.

• MeSH
• DNA bakterií biosyntéza   MeSH
• DNA-polymerasa III metabolismus   MeSH
• DNA-topoisomerasy typu II metabolismus   MeSH
• Enterococcus faecalis účinky léků   růst a vývoj   metabolismus   MeSH
• hydroxyfenylazouracil farmakologie   MeSH
• kyselina nalidixová farmakologie   MeSH
• mitomyciny farmakologie   MeSH
• uracil analogy a deriváty   MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• DNA bakterií MeSH
• DNA-polymerasa III MeSH
• DNA-topoisomerasy typu II MeSH
• hydroxyfenylazouracil MeSH
• kyselina nalidixová MeSH
• mitomyciny MeSH
• uracil MeSH