Nonspecificity of some commonly used inhibitors of DNA synthesis in cultures of Streptococcus faecalis
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
6277755
DOI
10.1007/bf02883830
Knihovny.cz E-zdroje
- MeSH
- DNA bakterií biosyntéza MeSH
- DNA-polymerasa III metabolismus MeSH
- DNA-topoisomerasy typu II metabolismus MeSH
- Enterococcus faecalis účinky léků růst a vývoj metabolismus MeSH
- hydroxyfenylazouracil farmakologie MeSH
- kyselina nalidixová farmakologie MeSH
- mitomyciny farmakologie MeSH
- uracil analogy a deriváty MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- DNA bakterií MeSH
- DNA-polymerasa III MeSH
- DNA-topoisomerasy typu II MeSH
- hydroxyfenylazouracil MeSH
- kyselina nalidixová MeSH
- mitomyciny MeSH
- uracil MeSH
The specificity of three commonly used inhibitors of DNA synthesis were tested in the batch culture of Streptococcus faecalis ATCC 8043 in rich broth medium. It was shown that nalidixic acid, mitomycin C and 6-(4-hydroxyphenylazo)uracil inhibit the growth of the cell mass as much as they decrease net DNA synthesis. Hence the drugs tested are highly unspecific inhibitors of DNA synthesis in S. faecalis; i.e. they all interfere with other processes as well as with DNA synthesis.
Zobrazit více v PubMed
Chem Biol Interact. 1977 Apr;17(1):113-6 PubMed
J Biol Chem. 1966 Jul 10;241(13):3083-9 PubMed
Proc Natl Acad Sci U S A. 1977 Nov;74(11):4767-71 PubMed
Annu Rev Biochem. 1977;46:641-68 PubMed
Appl Microbiol. 1972 Aug;24(2):179-83 PubMed
J Bacteriol. 1956 Feb;71(2):149-57 PubMed
Folia Microbiol (Praha). 1979;24(6):445-8 PubMed
