Paracoccus denitrificans cells undergo changes in protein composition upon exposure to azide, a known activator of the fumarate-nitrate reduction (FNR)-type transcription factor NarR. One of the most prominent protein species inducible by azide is a Fe/Mn-family superoxide dismutase (SOD). Azide induces SOD at protein, mRNA transcript, and enzyme activity levels in the aerobically growing cells. Since SOD expression remains unaffected in the fnrP-, nnr-, and narR-mutant strains, we postulate a mechanism independent of the known FNR-type regulators but involving a redox signal arising from the respiratory chain.

• MeSH
• Azides metabolism   MeSH
• Bacterial Proteins genetics   metabolism   MeSH
• Molecular Sequence Data MeSH
• Paracoccus denitrificans enzymology   genetics   MeSH
• Gene Expression Regulation, Enzymologic * MeSH
• Gene Expression Regulation, Bacterial MeSH
• Genes, Regulator * MeSH
• Amino Acid Sequence MeSH
• Superoxide Dismutase genetics   metabolism   MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Azides MeSH
• Bacterial Proteins MeSH
• Superoxide Dismutase MeSH