This review reports on inhibitors of copper-containing amine oxidases and flavoprotein polyamine oxidases, which are structurally based on diamines. In the introduction, basic characteristics and classification of amine oxidases are described together with the significance of their synthetic inhibitors. The following text is divided into several chapters, which deal with diaminoketones, aza-diamines, unsaturated diamine analogs and diamines with heterocyclic substituents. Then it continues with diamine- and agmatine-based inhibitors of polyamine oxidases. Each chapter gives detailed information on the inhibition mode, potency and structural relationships. The conclusion points out possible roles of mechanism-based inhibitors of amine oxidases in physiological and medicinal research.

• MeSH
• agmatin chemie   farmakologie   MeSH
• aktivace enzymů účinky léků   fyziologie   MeSH
• diaminy chemie   farmakologie   MeSH
• histaminasa antagonisté a inhibitory   metabolismus   MeSH
• inhibitory enzymů chemie   farmakologie   MeSH
• ketony chemie   farmakologie   MeSH
• lidé MeSH
• molekulární struktura MeSH
• oxidoreduktasy působící na CH-NH vazby antagonisté a inhibitory   metabolismus   MeSH
• polyaminoxidasa MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Názvy látek
• agmatin MeSH
• diaminy MeSH
• histaminasa MeSH
• inhibitory enzymů MeSH
• ketony MeSH
• oxidoreduktasy působící na CH-NH vazby MeSH