In normal rabbits and mice, one i.v. injection of scarlet fever toxin (ET) (30 000 STD per kg of rabbit weight or 20-g mouse) elicited a similar biphasic change in carbon clearance rate - early depression followed by a stimulating phase - as has been described for Gram-negative endotoxins. Prolonged depression without a subsequent stimulation phase was obtained in mice by raising the ET dose. The reasons of the discrepancy between these findings and those of Hanna and Watson (1965b) are discussed. Pyrogenic tolerance to ET is not accompanied by accelerated carbon clearance and is not impaired by RES blockade. A possible mechanism of ET tolerance is suggested.

• MeSH
• Bacterial Toxins pharmacology   MeSH
• Endotoxins pharmacology   MeSH
• Escherichia coli MeSH
• Exotoxins pharmacology   MeSH
• Phagocytosis drug effects   MeSH
• Fever chemically induced   MeSH
• Colloids MeSH
• Rabbits MeSH
• Metabolic Clearance Rate MeSH
• Mononuclear Phagocyte System drug effects   physiology   MeSH
• Mice MeSH
• Thorium Dioxide pharmacology   MeSH
• Salmonella paratyphi B MeSH
• Scarlet Fever microbiology   MeSH
• Streptococcus pyogenes analysis   MeSH
• Carbon metabolism   MeSH
• Animals MeSH
• Check Tag
• Rabbits MeSH
• Male MeSH
• Mice MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Comparative Study MeSH
• Names of Substances
• Bacterial Toxins MeSH
• Endotoxins MeSH
• Exotoxins MeSH
• Colloids MeSH
• Thorium Dioxide MeSH
• Carbon MeSH

• MeSH
• Cyclic AMP metabolism   MeSH
• Antilymphocyte Serum MeSH
• DNA biosynthesis   MeSH
• Endotoxins pharmacology   MeSH
• Freund's Adjuvant pharmacology   MeSH
• Macrophage Migration-Inhibitory Factors biosynthesis   MeSH
• Concanavalin A pharmacology   MeSH
• Rabbits MeSH
• Lectins pharmacology   MeSH
• Lymphocytes metabolism   MeSH
• Mitosis drug effects   MeSH
• Animals MeSH
• Check Tag
• Rabbits MeSH
• Male MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Cyclic AMP MeSH
• Antilymphocyte Serum MeSH
• DNA MeSH
• Endotoxins MeSH
• Freund's Adjuvant MeSH
• Macrophage Migration-Inhibitory Factors MeSH
• Concanavalin A MeSH
• Lectins MeSH

• MeSH
• Toxins, Biological * administration & dosage   MeSH
• Chinchilla MeSH
• Immune Tolerance MeSH
• Cortisone therapeutic use   MeSH
• Leukocytes * MeSH
• Leukopenia chemically induced   MeSH
• Scarlet Fever immunology   MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Toxins, Biological * MeSH
• Cortisone MeSH

• MeSH
• Toxins, Biological toxicity   MeSH
• Endotoxins toxicity   MeSH
• Fever chemically induced   MeSH
• Hydrocortisone pharmacology   MeSH
• Cortisone pharmacology   MeSH
• Skin Manifestations * MeSH
• Rabbits MeSH
• Salmonella typhi MeSH
• Scarlet Fever MeSH
• Streptococcus MeSH
• Animals MeSH
• Check Tag
• Rabbits MeSH
• Male MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Toxins, Biological MeSH
• Endotoxins MeSH
• Hydrocortisone MeSH
• Cortisone MeSH

• MeSH
• Toxins, Biological pharmacology   MeSH
• Endotoxins pharmacology   MeSH
• Rabbits MeSH
• Leukocytes * MeSH
• Pyrogens pharmacology   MeSH
• Salmonella paratyphi A * MeSH
• Streptococcus * MeSH
• Body Temperature MeSH
• Animals MeSH
• Check Tag
• Rabbits MeSH
• Male MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Toxins, Biological MeSH
• Endotoxins MeSH
• Pyrogens MeSH