Occupational hepatitis B remains a threat to healthcare workers (HCWs) worldwide, even with availability of an effective vaccine. Despite limited resources for public health, the Czech Republic instituted a mandatory vaccination program for HCWs in 1983. Annual incidence rates of acute hepatitis B were followed prospectively through 1995. Despite giving vaccine intradermally from 1983 to 1989 and intramuscularly as half dose from 1990 to 1995, rates of occupational hepatitis B decreased dramatically, from 177 cases per 100,000 workers in 1982 (before program initiated) to 17 cases per 100,000 in 1995. Among high-risk workers, the effect was even more dramatic (from 587 to 23 per 100,000). We conclude that strong public-health leadership led to control of occupational hepatitis B among HCWs in the Czech Republic, despite limited resources that precluded administering full-dose intramuscular vaccine for much of the program. Application of a similar program should be considered for other countries in regions that currently do not have a hepatitis B vaccination program.

• MeSH
• Disease Outbreaks prevention & control   MeSH
• Hepatitis B epidemiology   transmission   MeSH
• Dose-Response Relationship, Immunologic MeSH
• Incidence MeSH
• Humans MeSH
• Occupational Diseases epidemiology   MeSH
• Infectious Disease Transmission, Patient-to-Professional prevention & control   MeSH
• Risk Factors MeSH
• Hepatitis B Vaccines therapeutic use   MeSH
• Vaccination statistics & numerical data   MeSH
• Health Behavior MeSH
• Health Personnel * MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Research Support, U.S. Gov't, P.H.S. MeSH
• Geographicals
• Czech Republic epidemiology   MeSH
• Names of Substances
• Hepatitis B Vaccines MeSH