Ten E. coli K1 strains isolated from the urine of children with urinary tract infections were sensitive to the bactericidal action of normal human serum (NHS). The role of the particular mechanisms of complement activation was determined in the process of killing these strains, showing variable sensitivity to the bactericidal action of NHS; three mechanisms of activation of human complement were observed. Important role of alternative pathway activation in the bactericidal action of NHS against E. coli K1 strains independent of the classical and lectin pathways was not established.

• MeSH
• Complement Activation * MeSH
• Complement Pathway, Alternative MeSH
• Antigens, Bacterial immunology   MeSH
• Antigens, Surface immunology   MeSH
• Blood Bactericidal Activity MeSH
• Child MeSH
• Escherichia coli immunology   isolation & purification   MeSH
• Urinary Tract Infections microbiology   MeSH
• Escherichia coli Infections microbiology   MeSH
• Complement Pathway, Classical MeSH
• Complement Pathway, Mannose-Binding Lectin immunology   MeSH
• Humans MeSH
• Microbial Viability MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Antigens, Bacterial MeSH
• Antigens, Surface MeSH