Some patients with immunodeficiency develop clinical features of autoimmune disorders. A previously asymptomatic antibody deficiency can underlie the development of autoimmune diseases and a severe course of infection, with a risk of sepsis; such cases are known in selective IgA deficiency. On the other hand, little information is available on selective IgG subclass deficiencies. An unexpectedly severe course of Campylobacter infection in a 19-year-old woman with a previously undiagnosed complex immune disorder, including selective IgG1 immunodeficiency, Hashimoto's autoimmune thyroiditis with hypothyroidism combined with Addison's disease presumably due to autoimmune adrenalitis, autoimmunity and allergy is described. The pathophysiological mechanisms of autoimmunity in latent humoral defects are discussed.

• MeSH
• Addisonova nemoc komplikace   MeSH
• alergie komplikace   MeSH
• Campylobacter jejuni izolace a purifikace   MeSH
• deficience IgG komplikace   MeSH
• dospělí MeSH
• Hashimotova nemoc komplikace   MeSH
• kampylobakterové infekce komplikace   mikrobiologie   MeSH
• lidé MeSH
• multiorgánové selhání * MeSH
• sepse komplikace   mikrobiologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• práce podpořená grantem MeSH