The antifungal effect of substituted 1-phenyl-5-mercaptotetrazoles was tested with Candida tropicalis, C. pseudotropicalis, C. mogii, Trichosporon cutaneum, Cryptococcus albidus and S. cerevisiae. Candida strains exhibited the lowest sensitivity to the compounds; the most sensitive was S. cerevisiae. The MIC values ranged from 40 to > 1000 mg/mL. The antifungal effect of halogenated compounds decreased in the series of bromo > chloro > fluoro derivatives. The electrochemical oxidation of substituted 1-phenyl-5-mercaptotetrazole derivatives in an acetonitrile medium was studied as a model for the enzymic oxidation of the substance, including study of the effect of water, perchloric and trifluoromethanesulfuric acids on E1/2 and I1. 5-Bis-(1-phenyltetrazolyl)disulfide, the compound with no antifungal effect, has been identified as the main oxidation product of 1-phenyl-5-mercaptotetrazole.

• MeSH
• Acetonitriles metabolism   MeSH
• Antifungal Agents pharmacology   MeSH
• Disulfides pharmacology   MeSH
• Electrolysis MeSH
• Fungi drug effects   MeSH
• Microbial Sensitivity Tests MeSH
• Tetrazoles pharmacology   MeSH
• Chromatography, High Pressure Liquid MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Comparative Study MeSH
• Names of Substances
• 1-phenyl-5-mercaptotetrazole MeSH Browser
• acetonitrile MeSH Browser
• Acetonitriles MeSH
• Antifungal Agents MeSH
• Disulfides MeSH
• Tetrazoles MeSH