UNLABELLED: Moderate regular consumption of alcoholic beverages is believed to protect against atherosclerosis but can also increase homocysteine or dimethylglycine, which are putative risk factors for atherosclerosis. We aimed (1) to investigate the effect of alcohol consumption on vitamins and several metabolites involved in one-carbon metabolism; and (2) to find the most effective way of decreasing homocysteine during moderate alcohol consumption. METHODS: Male volunteers (n = 117) were randomly divided into five groups: the wine-only group (control, 375 mL of white wine daily for one month) and four groups combining wine consumption with one of the supplemented substances (folic acid, betaine, and vitamins B12 or B₆). Significant lowering of homocysteine concentration after the drinking period was found in subjects with concurrent folate and betaine supplementation. Vitamin B12 and vitamin B₆ supplementation did not lead to a statistically significant change in homocysteine. According to a multiple linear regression model, the homocysteine change in the wine-only group was mainly determined by the interaction between the higher baseline homocysteine concentration and the change in dimethylglycine levels. Folate and betaine can attenuate possible adverse effects of moderate alcohol consumption. Dimethylglycine should be interpreted together with data on alcohol consumption and homocysteine concentration.

• Klíčová slova
• B-vitamins, betaine, dimethylglycine, homocysteine, moderate alcohol consumption,
• MeSH
• ateroskleróza etiologie   prevence a kontrola   MeSH
• dospělí MeSH
• homocystein krev   MeSH
• kyselina listová farmakologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lineární modely MeSH
• pití alkoholu škodlivé účinky   krev   MeSH
• potravní doplňky * MeSH
• sarkosin analogy a deriváty   krev   MeSH
• senioři MeSH
• víno škodlivé účinky   MeSH
• vitamin B 12 farmakologie   MeSH
• vitamin B komplex farmakologie   MeSH
• vitamin B6 farmakologie   MeSH
• zdraví dobrovolníci pro lékařské studie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• randomizované kontrolované studie MeSH
• Názvy látek
• dimethylglycine MeSH Prohlížeč
• homocystein MeSH
• kyselina listová MeSH
• sarkosin MeSH
• vitamin B 12 MeSH
• vitamin B komplex MeSH
• vitamin B6 MeSH