Rheumatoid arthritis (RA) and its animal model adjuvant arthritis (AA) are inflammatory diseases characterized by chronic inflammation, systemic oxidative stress and disturbed mitochondrial bioenergetics of skeletal muscle. The present study aimed to evaluate the effects of coenzyme Q10 - CoQ10 (100 mg/kg b.w.), omega-3-polyunsaturated fatty acids - omega-3-PUFA (400 mg/kg b.w.) and their combined treatment in AA on impaired skeletal muscle mitochondrial bioenergetics, inflammation and changes in levels CoQ9 and CoQ10 in plasma. Markers of inflammation (C-reactive protein, monocyte-chemotactic protein-1), antioxidant capacity of plasma, respiratory chain parameters of skeletal muscle mitochondria and concentrations of CoQ9 and CoQ10 in plasma and in muscle tissue were estimated. Treatment of the arthritic rats with CoQ10, omega-3-PUFA alone and in combination partially reduced markers of inflammation and increased antioxidant capacity of plasma, significantly increased concentrations of coenzyme Q in mitochondria and improved mitochondrial function in the skeletal muscle. Combined treatment has similar effect on the mitochondrial function as monotherapies; however, it has affected inflammation and antioxidant status more intensively than monotherapies. Long-term supplementary administration of coenzyme Q10 and omega-3-PUFA and especially their combination is able to restore the impaired mitochondrial bioenergetics and antioxidant status in AA.

• MeSH
• antioxidancia metabolismus   MeSH
• artritida experimentální krev   dietoterapie   MeSH
• C-reaktivní protein metabolismus   MeSH
• chemokin CCL2 krev   MeSH
• krysa rodu Rattus MeSH
• omega-3 mastné kyseliny terapeutické užití   MeSH
• potkani inbrední LEW MeSH
• potravní doplňky MeSH
• revmatoidní artritida krev   dietoterapie   MeSH
• svalové mitochondrie metabolismus   MeSH
• ubichinon analogy a deriváty   metabolismus   terapeutické užití   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• hodnotící studie MeSH
• Názvy látek
• antioxidancia MeSH
• C-reaktivní protein MeSH
• chemokin CCL2 MeSH
• coenzyme Q10 MeSH Prohlížeč
• omega-3 mastné kyseliny MeSH
• ubichinon MeSH
• ubiquinone 9 MeSH Prohlížeč