Disorders of carbohydrate and lipid metabolism have been reported to cluster in patients with essential hypertension and in spontaneously hypertensive rats (SHRs). A deletion in the Cd36 gene on chromosome 4 has recently been implicated in defective carbohydrate and lipid metabolism in isolated adipocytes from SHRs. However, the role of Cd36 and chromosome 4 in the control of blood pressure and systemic cardiovascular risk factors in SHRs is unknown. In the SHR. BN-Il6/Npy congenic strain, we have found that transfer of a segment of chromosome 4 (including Cd36) from the Brown Norway (BN) rat onto the SHR background induces reductions in blood pressure and ameliorates dietary-induced glucose intolerance, hyperinsulinemia, and hypertriglyceridemia. These results demonstrate that a single chromosome region can influence a broad spectrum of cardiovascular risk factors involved in the hypertension metabolic syndrome. However, analysis of Cd36 genotypes in the SHR and stroke-prone SHR strains indicates that the deletion variant of Cd36 was not critical to the initial selection for hypertension in the SHR model. Thus, the ability of chromosome 4 to influence multiple cardiovascular risk factors, including hypertension, may depend on linkage of Cd36 to other genes trapped within the differential segment of the SHR. BN-Il6/Npy strain.

• MeSH
• antigeny CD36 genetika   MeSH
• cerebrovaskulární poruchy genetika   patofyziologie   MeSH
• fenotyp MeSH
• genotyp MeSH
• hemodynamika genetika   MeSH
• hypertenze genetika   patofyziologie   MeSH
• inzulin krev   genetika   MeSH
• krevní glukóza genetika   metabolismus   MeSH
• krysa rodu Rattus MeSH
• lipidy krev   genetika   MeSH
• potkani inbrední BN MeSH
• potkani inbrední SHR MeSH
• rizikové faktory MeSH
• sekvenční delece MeSH
• shluková analýza MeSH
• zvířata kongenní MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Research Support, U.S. Gov't, P.H.S. MeSH
• Názvy látek
• antigeny CD36 MeSH
• inzulin MeSH
• krevní glukóza MeSH
• lipidy MeSH