Most cited article - PubMed ID 17571790
Antimicrobial activity of a series of thiosemicarbazones and their Zn(II) and Pd(II) complexes
Seven hypotheses on relationships between the structure of naphthalene analogs and bioluminescence response of bioreporter Pseudomonas fluorescens were formulated using GUHA (General Unary Hypotheses Automaton) on a training set of 37 compounds. Prediction of bioluminescence response of 12 new naphthalene analogs was successful in 69 % cases and resulted in rejection of single hypothesis. The results demonstrate applicability of GUHA in structure-activity research, especially for qualitative data.
- MeSH
- Biosensing Techniques MeSH
- Luminescent Measurements MeSH
- Naphthalenes chemistry metabolism pharmacology MeSH
- Pseudomonas fluorescens drug effects metabolism MeSH
- Genes, Reporter * MeSH
- Structure-Activity Relationship MeSH
- Green Fluorescent Proteins genetics metabolism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Naphthalenes MeSH
- naphthalene MeSH Browser
- Green Fluorescent Proteins MeSH
Synthesis and antimicrobial activity of novel 1-methyl-3-alkylthio-4-aminoquinolinium salts 2 and 1-methyl-3-acylthio-4-aminoquinolinium salts 4 are described. Compounds 2 were obtained by reacting 1-methyl-3,4-(dimethylthio)quinolinium chloride 1 with amines and by reacting 1-methyl-4-aminoquinolinium-3-thiolates 3 with alkylating agents. Compounds 4 were obtained by the reaction of 1-methyl-4-aminoquinolinium-3-thiolates 3 with acylating agents. Antimicrobial activity of compounds 2 and 4 was determined using G+ (Staphylococcus aureus, Enterococcus faecalis) and G(-) (Escherichia coli, Pseudomonas aeruginosa) strains as well as Candida albicans yeast. The compounds show greatest activity against S. aureus whereas the lowest against P. aeruginosa.
- MeSH
- Aminoquinolines chemical synthesis chemistry pharmacology MeSH
- Anti-Infective Agents chemical synthesis chemistry pharmacology MeSH
- Candida albicans drug effects MeSH
- Gram-Negative Bacteria drug effects MeSH
- Gram-Positive Bacteria drug effects MeSH
- Magnetic Resonance Spectroscopy MeSH
- Microbial Sensitivity Tests MeSH
- Microbial Viability drug effects MeSH
- Molecular Structure MeSH
- Sulfides chemistry MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Aminoquinolines MeSH
- Anti-Infective Agents MeSH
- Sulfides MeSH
