Azinyl sulfides--CXVIII. Antimicrobial activity of novel 1-methyl-3-thio-4-aminoquinolinium salts
Language English Country United States Media print-electronic
Document type Journal Article
- MeSH
- Aminoquinolines chemical synthesis chemistry pharmacology MeSH
- Anti-Infective Agents chemical synthesis chemistry pharmacology MeSH
- Candida albicans drug effects MeSH
- Gram-Negative Bacteria drug effects MeSH
- Gram-Positive Bacteria drug effects MeSH
- Magnetic Resonance Spectroscopy MeSH
- Microbial Sensitivity Tests MeSH
- Microbial Viability drug effects MeSH
- Molecular Structure MeSH
- Sulfides chemistry MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Aminoquinolines MeSH
- Anti-Infective Agents MeSH
- Sulfides MeSH
Synthesis and antimicrobial activity of novel 1-methyl-3-alkylthio-4-aminoquinolinium salts 2 and 1-methyl-3-acylthio-4-aminoquinolinium salts 4 are described. Compounds 2 were obtained by reacting 1-methyl-3,4-(dimethylthio)quinolinium chloride 1 with amines and by reacting 1-methyl-4-aminoquinolinium-3-thiolates 3 with alkylating agents. Compounds 4 were obtained by the reaction of 1-methyl-4-aminoquinolinium-3-thiolates 3 with acylating agents. Antimicrobial activity of compounds 2 and 4 was determined using G+ (Staphylococcus aureus, Enterococcus faecalis) and G(-) (Escherichia coli, Pseudomonas aeruginosa) strains as well as Candida albicans yeast. The compounds show greatest activity against S. aureus whereas the lowest against P. aeruginosa.
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