We studied the effect of food restriction, overfeeding, and normofeeding on cachexia, inflammatory and metabolic parameters, and insulin sensitivity in chronic adjuvant arthritis (AA) in rats. Food restriction during AA increased circulating ghrelin, corticosterone, decreased leptin, and ameliorated arthrogram score and systemic inflammation compared to normofeeding. Overfeeding worsened arthrogram score and systemic inflammation, and led to lipid accumulation in the liver, but not to alterations of adipokine and ghrelin plasma levels relative to normofeeding. Independently of feeding status, AA induced cachexia, in which modulation of mRNA expressions for appetite-regulating neuropeptides (NPY, AgRP, POMC, CART) in the arcuate nucleus (ARC) does not play a primary role. The overexpression of IL-1β mRNA in the ARC suggests its role in the mechanisms of impaired energy balance during AA under all feeding conditions. Normal HOMA index in all arthritic groups does not indicate the development of insulin resistance by feeding interventions in these rats.

• MeSH
• adipokiny metabolismus   MeSH
• adjuvantní chemoterapie metody   MeSH
• artritida dietoterapie   terapie   MeSH
• ghrelin metabolismus   MeSH
• hormony kůry nadledvin metabolismus   MeSH
• inzulin metabolismus   MeSH
• kachexie metabolismus   MeSH
• krmivo pro zvířata * MeSH
• krysa rodu Rattus MeSH
• leptin metabolismus   MeSH
• neuropeptidy chemie   MeSH
• nucleus arcuatus hypothalami metabolismus   MeSH
• potkani inbrední LEW MeSH
• zánět MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• adipokiny MeSH
• ghrelin MeSH
• hormony kůry nadledvin MeSH
• inzulin MeSH
• leptin MeSH
• neuropeptidy MeSH