Mucormycosis is a rare fungal infection in immunocompetent patients, whereas in immunocompromised, it may be systemic and disseminated infection associated with high mortality. Mucormycosis is one of the most rapidly progressing and fulminant forms of fungal infections; Mucor circinelloides is rarely isolated species, also from immunocompromised patients. The reported case of mucormycosis after a traffic accident indicates that it may be the result of a contamination of wound by M. circinelloides coming from the environment. The fungal strain was identified by phenotypic methods and confirmed by molecular methods. Etest method was used for susceptibility testing of the fungal strain. No mycotoxins were detected in the analyzed sample. The infection was successfully treated with amphotericin B, but amputation of the lower limb was necessary.

• MeSH
• amputace MeSH
• antifungální látky farmakologie   MeSH
• diskové difúzní antimikrobiální testy MeSH
• dolní končetina patologie   MeSH
• dopravní nehody * MeSH
• dospělí MeSH
• lidé MeSH
• Mucor genetika   izolace a purifikace   MeSH
• mukormykóza diagnóza   etiologie   MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• antifungální látky MeSH

A case report of cutaneous mucormycosis and obstacles to early diagnosis is presented. A 38-year-old male was involved in a car accident that led to amputation of both lower limbs. Subsequently, he developed fungal wound infection of the left lower limb stump. The infection was detected very early, although the diagnosis was difficult because only a small area was affected and histopathological examination was initially negative. The infection was proven by microscopy, culture and histopathology. The isolate was identified by sequencing of the rDNA ITS region gene (internal transcribed spacer region of ribosomal DNA) as Lichtheimia corymbifera. Liposomal amphotericin B and surgery were successful in management of the disease.

• Klíčová slova
• Amphotericin B, Cutaneous mucormycosis, Lichtheimia corymbifera, Mycological diagnosis,
• MeSH
• amfotericin B aplikace a dávkování   MeSH
• antifungální látky aplikace a dávkování   MeSH
• časná diagnóza MeSH
• debridement MeSH
• DNA fungální chemie   genetika   MeSH
• dopravní nehody MeSH
• dospělí MeSH
• histocytochemie MeSH
• infekce v ráně diagnóza   mikrobiologie   patologie   MeSH
• lidé MeSH
• mezerníky ribozomální DNA chemie   genetika   MeSH
• mikroskopie MeSH
• Mucorales klasifikace   genetika   izolace a purifikace   MeSH
• mukormykóza diagnóza   mikrobiologie   patologie   MeSH
• rány a poranění komplikace   MeSH
• sekvenční analýza DNA MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• amfotericin B MeSH
• antifungální látky MeSH
• DNA fungální MeSH
• liposomal amphotericin B MeSH Prohlížeč
• mezerníky ribozomální DNA MeSH