• MeSH
• gadolinium MeSH
• kontrastní látky * MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• mozečková jádra MeSH
• následné studie MeSH
• organokovové sloučeniny * MeSH
• retrospektivní studie MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• dopisy MeSH
• práce podpořená grantem MeSH
• Názvy látek
• gadolinium MeSH
• kontrastní látky * MeSH
• organokovové sloučeniny * MeSH

INTRODUCTION: Glioblastoma (GBM) is the most common malignant primary brain tumor, and methods to improve the early detection of disease progression and evaluate treatment response are highly desirable. We therefore explored changes in whole-brain apparent diffusion coefficient (ADC) values with respect to survival (progression-free [PFS], overall [OS]) in a cohort of GBM patients followed at regular intervals until disease progression. METHODS: A total of 43 subjects met inclusion criteria and were analyzed retrospectively. Histogram data were extracted from standardized whole-brain ADC maps including skewness, kurtosis, entropy, median, mode, 15th percentile (p15) and 85th percentile (p85) values, and linear regression slopes (metrics versus time) were fitted. Regression slope directionality (positive/negative) was subjected to univariate Cox regression. The final model was determined by aLASSO on metrics above threshold. RESULTS: Skewness, kurtosis, median, p15 and p85 were all below threshold for both PFS and OS and were analyzed further. Median regression slope directionality best modeled PFS (p = 0.001; HR 3.3; 95% CI 1.6-6.7), while p85 was selected for OS (p = 0.002; HR 0.29; 95% CI 0.13-0.64). CONCLUSIONS: Our data show tantalizing potential in the use of whole-brain ADC measurements in the follow up of GBM patients, specifically serial median ADC values which correlated with PFS, and serial p85 values which correlated with OS. Whole-brain ADC measurements are fast and easy to perform, and free of ROI-placement bias.

• Klíčová slova
• Apparent diffusion coefficient, Diffusion-weighted imaging, Glioblastoma, Histogram analyses, Magnetic resonance imaging,
• MeSH
• alkylační protinádorové látky terapeutické užití   MeSH
• chemoradioterapie mortalita   MeSH
• difuzní magnetická rezonance metody   MeSH
• glioblastom mortalita   patologie   terapie   MeSH
• kombinovaná terapie MeSH
• lidé MeSH
• míra přežití MeSH
• nádory mozku mortalita   patologie   terapie   MeSH
• následné studie MeSH
• počítačové zpracování obrazu metody   MeSH
• prognóza MeSH
• progrese nemoci MeSH
• retrospektivní studie MeSH
• temozolomid terapeutické užití   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• alkylační protinádorové látky MeSH
• temozolomid MeSH