The first three children with Puumala virus nephropathy diagnosis in the Czech Republic are reported on. A boy and two girls were admitted with symptoms of interstitial nephritis. The medical history in all children revealed flu-like symptoms. All patients were mildly pyrexial and had elevated erythrocytes sedimentation rate, C-reactive protein and low hemoglobin levels. Serum creatinine levels were elevated and proteinuria exceeded 700 mg/L in all children. Tubular proteinuria, glycosuria, high urinary N-acetyl-beta-D-glucosaminidase levels and alpha-1-microglobulin levels confirmed the tubular lesion. Renal biopsies revealed a uniform pattern and showed non-purulent interstitial nephritis in all patients. Puumala virus antigen antibodies were detected in the plasma. All patients were treated with steroids and urine abnormalities and renal function returned to normal within 4 weeks. Hantavirus infection should be considered as one of possible causes of interstitial nephritis with decreased GFR in children even in areas with a low incidence of this infection.

• MeSH
• diferenciální diagnóza MeSH
• dítě MeSH
• hantavirové infekce diagnóza   epidemiologie   MeSH
• Hantavirus * MeSH
• hemoragická horečka s renálním syndromem diagnóza   patofyziologie   MeSH
• lidé MeSH
• mladiství MeSH
• progrese nemoci MeSH
• virus Puumala * MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

• MeSH
• hantavirové infekce epidemiologie   imunologie   prevence a kontrola   MeSH
• Hantavirus imunologie   izolace a purifikace   MeSH
• hlodavci virologie   MeSH
• imunoglobulin G analýza   MeSH
• imunoglobulin M analýza   MeSH
• lidé MeSH
• protilátky virové krev   MeSH
• séroepidemiologické studie MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• dopisy MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Česká republika epidemiologie   MeSH
• Názvy látek
• imunoglobulin G MeSH
• imunoglobulin M MeSH
• protilátky virové MeSH