The EEG theta band displays distinct roles in resting and task states. Low resting theta and transient increases in frontal-midline (fm) theta power during tasks are associated with better cognitive control, such as error monitoring. ADHD can disrupt this balance, resulting in high resting theta linked to drowsiness and low fm-theta activity associated with reduced cognitive abilities. Theta/beta ratio (TBR) neurofeedback aims to normalize resting state activity by downregulating theta, which could potentially unfavorably affect task-related fm-theta. This study examines the TBR neurofeedback's impact on both resting and fm-theta activity, hypothesizing that remission depends on these effects. We analyzed data from a multi-center, double-blind randomized controlled trial with 142 children with ADHD and high TBR (ICAN study). Participants were randomized into experimental or sham NF groups. EEG measurements were taken at rest and during an Oddball task before and after neurofeedback, assessing global electrodes for resting theta and fm electrodes during error dynamics. Post-intervention changes were calculated as differences, and ANOVAs were conducted on GROUP, REMISSION, and CONDITION variables. Final analysis included fewer participants for all analyses. Resting state analysis showed no significant effects on global or fm-theta after TBR neurofeedback. Error dynamics analysis was inconclusive for global and fm-theta in both remitters and non-remitters. Results suggest that the current TBR neurofeedback protocol did not reduce aberrant resting state theta, and emphasize the need for refined protocols targeting specific theta-band networks to reduce resting-state theta without affecting fm-theta related to cognitive control.

• Klíčová slova
• Children with ADHD, Error-related dynamics, Fm-theta, ICAN study, Task-related and resting state theta, Theta–beta ratio neurofeedback,
• Publikační typ
• časopisecké články MeSH

INTRODUCTION: The COVID-19 pandemic and its related restrictions, mainly social distancing, had an impact on the mental health of various groups, including adolescents. METHODS: The main goal of our study was to explore the impact of gender, age, resilience (measured using the Brief Resilience Scale), attachment anxiety, attachment avoidance (both measured using the Experiences in Close Relationships Revised Scale for adolescents), and mental and general health (measured using items of SF-8 Health Survey) on COVID anxiety (measured using the COVID Anxiety Scale) among a sample of Slovak adolescents (N = 1,786, age 15 to 19, mean age = 16.8, SD = 1.2). The data were collected online between 13 April and 24 May 2021. RESULTS: Four nested linear regression models were fitted to the data and evaluated. The significant predictors that had a greater effect than our smallest effect size of interest (β = 0.10) were gender (β = -0.26, p < 0.001, where boys had lower scores in COVID anxiety), general and mental health (β = -0.13 and β = -0.14, respectively, both with p < 0.001), resilience (β = -0.12, p < 0.001), and attachment avoidance (β = -0.11, p < 0.001). Similarly, age and attachment anxiety were significant predictors with a lower effect size (β = 0.06, p = 0.003, and β = 0.09, p < 0.001, respectively). DISCUSSION: Our results are in line with previous research findings highlighting the importance of prevention and interventions programs focused mainly on preventing loneliness and social disconnection, fostering secure attachment with parents and peers, and increasing the resilience of adolescents, especially in the stressful time of a pandemic, to promote their mental health.

• Klíčová slova
• COVID anxiety, COVID-19, adolescents, attachment, general health, resilience,
• Publikační typ
• časopisecké články MeSH

BACKGROUND: Gender discrimination may be a novel mechanism through which gender inequality negatively affects the health of women and girls. We investigated whether children's mental health varied with maternal exposure to perceived gender discrimination. METHODS: Complete longitudinal data was available on 2,567 mother-child dyads who were enrolled between March 1, 1991 and June 30, 1992 in the European Longitudinal Cohort Study of Pregnancy and Childhood-Czech cohort and were surveyed at multiple time points between pregnancy and child age up to 15 years. The Strengths and Difficulties Questionnaire (SDQ) was administered at child age 7, 11, and 15 years to assess child emotional/behavioural difficulties. Perceived gender discrimination was self-reported in mid-pregnancy and child age 7 and 11 years. Multilevel mixed-effects linear regression of SDQ scores were estimated. Mediation was tested using structural equation models. FINDINGS: Perceived gender discrimination, reported by 11.2% of mothers in mid-pregnancy, was related to increased emotional/behavioural difficulties among children in bivariate analysis (slope = 0.24 [95% confidence interval (CI): 0.15, 0.32], p<0.0001) and in the fully adjusted model (slope = 0.18 [95% CI: 0.09, 0.27], p<0.0001). Increased difficulties were evident among children of mothers with more depressive symptoms (slope = 0.04 [95% CI: 0.03, 0.05], p<0.0001), boys (slope = 0.26 [95% CI: 0.19, 0.34], p<0.0001), first children (slope = 0.16 [95% CI: 0.09, 0.23], p<0.0001), and families under financial hardship (slope = 0.09 [95% CI: 0.04, 0.14], p<0.0001). Effects were attenuated for married mothers (slope-0.12 [95% CI: -0.22, -0.01], p<0.05]. Maternal depressive symptoms and financial hardship mediated about 37% and 13%, respectively, of the total effect of perceived gender discrimination on SDQ scores. INTERPRETATION: Perceived gender discrimination among child-bearing women in family contexts was associated with more mental health problems among their children and adolescents, extending prior research showing associations with maternal mental health problems. Maternal depressive symptoms and, to a lesser extent, financial hardship both partially mediated the positive relationship between perceived gender discrimination and child emotional/behavioural problems. This should be taken into consideration when measuring the societal burden of gender inequality and gender-based discrimination. Moreover, gender-based discrimination affects more than one gender and more than one generation, extending to boys in the household even moreso than girls, highlighting that gender discrimination is everyone's issue. Further research is required on the intergenerational mechanisms whereby gender discrimination may lead to maternal and child mental health consequences. FUNDING: Bill and Melinda Gates Foundation; Ministry of Education, Youth and Sports, Czech Republic and European Structural and Investment Funds.

• Klíčová slova
• Adolescent health, Adverse childhood experiences, Behavioural problems, Child health, Gender discrimination, Mental health,
• Publikační typ
• časopisecké články MeSH

Mental disorders affect 10-20 % of the young population in the world. Major depressive disorder (MDD) is a common mental disease with a multifactorial and not clearly explained pathophysiology. Many cases remain undetected and untreated, which influences patients' physical and mental health and their quality of life also in adulthood. The aim of our pilot study was to assess the prediction value of selected potential biomarkers, including blood cell counts, blood cell ratios, and parameters like peroxiredoxin 1 (PRDX1), tenascin C (TNC) and type IV collagen (COL4) between depressive pediatric patients and healthy peers and to evaluate a short effect of antidepressant treatment. In this study, 27 young depressive patients and 26 non-depressed age-matched controls were included. Blood analyses and immunological assays using commercial kits were performed. Platelet count was the only blood parameter for which the case/control status was statistically significant (p=0.01) in a regression model controlling for the age and gender differences. The results from ELISA analyses showed that the case/control status is a significant predictor of the parameters PRDX1 (p=0.05) and COL4 (p=0.009) in respective regression model considering the age and gender differences between MDD patients and controls. A major finding of this study is that values of platelet count, monocyte to lymphocyte ratio, white blood cell, and monocyte counts were assessed by the Random Forest machine learning algorithm as relevant predictors for discrimination between MDD patients and healthy controls with a power of prediction AUC=0.749.

• MeSH
• biologické markery analýza   MeSH
• depresivní porucha unipolární diagnóza   epidemiologie   psychologie   MeSH
• kvalita života MeSH
• lidé MeSH
• mladiství MeSH
• pilotní projekty MeSH
• studie případů a kontrol MeSH
• Check Tag
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Slovenská republika epidemiologie   MeSH
• Názvy látek
• biologické markery MeSH

This article is a summary of perspectives on training curricula from child and adolescent psychiatry trainees globally. We aimed to identify the relative strengths, weaknesses and gaps in learning needs from a trainee's perspective. The 20 early-career child psychiatrists who contributed are from 16 countries and represent all the five continents. We could identify some global challenges as well as local/regional challenges that need to be addressed to develop competent child psychiatrists.

• Klíčová slova
• Child psychiatry, curriculum development, education and training,
• Publikační typ
• časopisecké články MeSH