Supersaturation of body fluids, specifically of plasma and urine, with respect to biological hydroxyapatite was evaluated taking into account calcium complexation, fraction of total phosphorus present as hydrogen phosphate ions, solubility of carbonated hydroxyapatite and the size dependency of equilibrium solubility. Plasma is always supersaturated with respect to apatitic solid phase and thus calcific deposits are formed unless a sufficient quantity of potent inhibitors is present. When urinary pH is lower than 6.3 for normal urine hydroxyapatite cannot appear in renal stones, at higher pH apatitic renal stones can be formed. Predictions based on supersaturation calculated for different conditions correspond well with clinical observations.

• MeSH
• biologické modely * MeSH
• fosfáty krev   moč   MeSH
• hydroxyapatit krev   moč   MeSH
• koncentrace vodíkových iontů MeSH
• lidé MeSH
• tělesné tekutiny metabolismus   MeSH
• vápník krev   moč   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• fosfáty MeSH
• hydroxyapatit MeSH
• vápník MeSH