Mucormycosis is an aggressive fungal infection, which invades endothelial cells of blood vessels. This condition might lead to destruction of endothelium and release of heparin-like substances to the bloodstream and cause life-threatening bleeding, which is not well described in the literature.We present a patient with mucormycosis who experienced life-threatening bleeding, although no standard laboratory test could detect any coagulopathy.The cause of bleeding-coagulopathy was detected only by nonactivated thromboelastometry (NATEM), which revealed the presence of heparin-like substances. After treatment with recombinant activated FVII rotational thromboelastometry, results improved and the patient stopped bleeding. Regular application of the drug was necessary during acute phase of infection to prevent further bleeding.In this case report, we show that NATEM can detect the presence of heparin-like substances in bleeding patient with mucormycosis infection and that recombinant activated FVII can be used to stop and prevent bleeding until infection resolves.

• MeSH
• Antifungal Agents therapeutic use   MeSH
• Child MeSH
• Drainage adverse effects   MeSH
• Factor VIIa therapeutic use   MeSH
• Heparinoids metabolism   MeSH
• Iatrogenic Disease MeSH
• Hemorrhage etiology   therapy   MeSH
• Humans MeSH
• Mucormycosis drug therapy   metabolism   MeSH
• Recombinant Proteins therapeutic use   MeSH
• Spleen injuries   surgery   MeSH
• Splenectomy MeSH
• Blood Coagulation Tests * MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Case Reports MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Antifungal Agents MeSH
• Factor VIIa MeSH
• Heparinoids MeSH
• recombinant FVIIa MeSH Browser
• Recombinant Proteins MeSH