The endometrium tissue is functionally androgen related which plays an important role in women's fertility regulation. In addition recent findings show that endometrium related pathology is closely linked to disrupted androgen biosynthesis and associated regulatory functions. These findings also suggest that androgens might play an important role in endometrium related cancer pathology with significant implications for treatment.Based on these findings, we have assessed 50 female outpatients with endometriosis and the clinical investigations were focused on biochemical serum analysis of DHEAS, oncological markers CA-125 and CA 19-9, estradiol, thyreothropic hormone, and prolactin.The results show significant Spearman correlations of CA-125 and CA 19-9 with dehydroepiandrosterone- DHEA-S (R = 0.52 resp. R = 0.49).This result represents 1st reported finding documenting androgen related increase of CA-125 and CA 19-9 levels as significant markers of endometrium pathology and it is possible to assume that these potential biomarkers could have clinical importance with respect to timely diagnosis.

• MeSH
• antigen CA-125 krev   MeSH
• antigen CA-19-9 krev   MeSH
• dehydroepiandrosteronsulfát krev   MeSH
• dospělí MeSH
• endometrióza krev   MeSH
• lidé MeSH
• nádorové biomarkery krev   MeSH
• nádory endometria krev   diagnóza   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• pozorovací studie MeSH
• Názvy látek
• antigen CA-125 MeSH
• antigen CA-19-9 MeSH
• dehydroepiandrosteronsulfát MeSH
• nádorové biomarkery MeSH