BACKGROUND This study was carried out to determine the relationship between the common TMEM-18 (rs4854344, G>T) and NYD-SP18 (rs6971091, G>A) gene variants and weight loss after lifestyle interventions (increased physical activity in conjunction with optimal dietary intake) in overweight/obese children/adolescents. MATERIAL AND METHODS We genotyped 684 unrelated, white, non-diabetic children (age 12.7±2.1 years, average BMI at baseline 30.66±4.80 kg/m²). Anthropometric and biochemical examinations were performed before and after 4 weeks of an intensive lifestyle intervention. RESULTS The mean weight loss achieved was 5.20±2.02 kg (P<0.001). NYDSP-18 AA homozygotes had significantly higher abdominal skinfold value before and after the intervention (both, P=0.001). No significant associations between BMI decrease and the NYD-SP18 and TMEM18 variants were found. Associations between all anthropometrical and biochemical changes and genes remained non-significant after data were adjusted for sex, age, and baseline values. CONCLUSIONS Decreased body weight in overweight/obese children is not significantly influenced by the NYD-SP18 rs6971091 or TMEM18 rs4854344 polymorphisms.

• MeSH
• Adiposity genetics   MeSH
• Exercise MeSH
• Child MeSH
• Genotype MeSH
• Weight Loss genetics   MeSH
• Body Mass Index MeSH
• Nuclear Proteins genetics   metabolism   MeSH
• Polymorphism, Single Nucleotide MeSH
• Humans MeSH
• Membrane Proteins genetics   metabolism   MeSH
• Adolescent MeSH
• Overweight genetics   MeSH
• Obesity genetics   MeSH
• Body Weight genetics   MeSH
• Life Style MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Adolescent MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• FAM71F1 protein, human MeSH Browser
• Nuclear Proteins MeSH
• Membrane Proteins MeSH
• TMEM18 protein, human MeSH Browser