Body Adiposity Changes After Lifestyle Interventions in Children/Adolescents and the NYD-SP18 and TMEM18 Variants
Jazyk angličtina Země Spojené státy americké Médium electronic
Typ dokumentu časopisecké články
PubMed
30341978
PubMed Central
PMC6204654
DOI
10.12659/msm.907180
PII: 907180
Knihovny.cz E-zdroje
- MeSH
- adipozita genetika MeSH
- cvičení MeSH
- dítě MeSH
- genotyp MeSH
- hmotnostní úbytek genetika MeSH
- index tělesné hmotnosti MeSH
- jaderné proteiny genetika metabolismus MeSH
- jednonukleotidový polymorfismus MeSH
- lidé MeSH
- membránové proteiny genetika metabolismus MeSH
- mladiství MeSH
- nadváha genetika MeSH
- obezita genetika MeSH
- tělesná hmotnost genetika MeSH
- životní styl MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- FAM71F1 protein, human MeSH Prohlížeč
- jaderné proteiny MeSH
- membránové proteiny MeSH
- TMEM18 protein, human MeSH Prohlížeč
BACKGROUND This study was carried out to determine the relationship between the common TMEM-18 (rs4854344, G>T) and NYD-SP18 (rs6971091, G>A) gene variants and weight loss after lifestyle interventions (increased physical activity in conjunction with optimal dietary intake) in overweight/obese children/adolescents. MATERIAL AND METHODS We genotyped 684 unrelated, white, non-diabetic children (age 12.7±2.1 years, average BMI at baseline 30.66±4.80 kg/m²). Anthropometric and biochemical examinations were performed before and after 4 weeks of an intensive lifestyle intervention. RESULTS The mean weight loss achieved was 5.20±2.02 kg (P<0.001). NYDSP-18 AA homozygotes had significantly higher abdominal skinfold value before and after the intervention (both, P=0.001). No significant associations between BMI decrease and the NYD-SP18 and TMEM18 variants were found. Associations between all anthropometrical and biochemical changes and genes remained non-significant after data were adjusted for sex, age, and baseline values. CONCLUSIONS Decreased body weight in overweight/obese children is not significantly influenced by the NYD-SP18 rs6971091 or TMEM18 rs4854344 polymorphisms.
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