The Impact of Physical Activity and Dietary Measures on the Biochemical and Anthropometric Parameters in Obese Children. Is There Any Genetic Predisposition?
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
26849546
DOI
10.21101/cejph.a4191
Knihovny.cz E-zdroje
- Klíčová slova
- child obesity, genetic predisposition, regimen intervention, risk factors,
- MeSH
- antropometrie MeSH
- ateroskleróza genetika MeSH
- dítě MeSH
- dyslipidemie genetika MeSH
- energetický příjem MeSH
- gen pro FTO MeSH
- genetická predispozice k nemoci * MeSH
- genotyp MeSH
- lidé MeSH
- metabolický syndrom genetika MeSH
- mladiství MeSH
- obezita dětí a dospívajících genetika prevence a kontrola MeSH
- proteiny genetika MeSH
- receptor melanokortinový typ 4 genetika MeSH
- rizikové faktory MeSH
- životní styl MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
- Názvy látek
- FTO protein, human MeSH Prohlížeč
- gen pro FTO MeSH
- MC4R protein, human MeSH Prohlížeč
- proteiny MeSH
- receptor melanokortinový typ 4 MeSH
AIM: The aim of the study was to monitor the importance of laboratory, anthropometric and genetic determination of the presence of risk factors for atherosclerosis, obesity, dyslipidemia and components of the metabolic syndrome in obese children and the response to dietary and regimen interventions in obese children. METHODS: As a part of the study, 353 paediatric patients (46% boys, 54% girls) with obesity and dyslipidemia, aged 8-16 years, participated in a one-month lifestyle intervention programme. The programme involved a reduction of energy intake and supervised exercise programme consisting of 5 exercise units per day, each 50 minutes long. Standard biochemical methods were applied, including Lp-PLA2, as were anthropometric measurements and genetic analyses. RESULTS: During the reduction programme for the children there was a statistically significant decrease in all anthropometric indicators of bodyweight (p<0.001) as well as in lipid parameters and LpLPA2. Carriers of the FTO GG genotype and/or MC4R CC genotype lost significantly more body weight in comparison to non-carriers. CONCLUSION: Child obesity is an important social issue. After regimen interventions, there is weight loss as well as an improvement in biochemical parameters. There are individuals with a genetic predisposition for obesity, as well as individuals with a better response to regimen interventions which could, among other things, be determined by the FTO and MC4R genotypes.
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