FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23201545
DOI
10.1016/j.clinbiochem.2012.11.017
PII: S0009-9120(12)00652-2
Knihovny.cz E-resources
- MeSH
- Child MeSH
- Energy Intake MeSH
- Gene Frequency MeSH
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO MeSH
- Epistasis, Genetic MeSH
- Genetic Association Studies MeSH
- Body Mass Index MeSH
- Humans MeSH
- Adolescent MeSH
- Overweight genetics therapy MeSH
- Obesity genetics therapy MeSH
- Polymorphism, Genetic MeSH
- Weight Reduction Programs MeSH
- Proteins genetics MeSH
- Receptor, Melanocortin, Type 4 genetics MeSH
- Diet, Reducing MeSH
- Sequence Analysis, DNA MeSH
- Exercise Therapy MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- FTO protein, human MeSH Browser
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO MeSH
- MC4R protein, human MeSH Browser
- Proteins MeSH
- Receptor, Melanocortin, Type 4 MeSH
OBJECTIVES: This study aimed to determine whether there is a relationship between common FTO (rs17817449) and MC4R (rs17782313) gene variants and body mass reduction or weight loss after a one-month lifestyle intervention in overweight/obese children. DESIGN AND METHODS: We genotyped 357 unrelated non-diabetic Czech children (age 13.7 ± 4.9 years, average BMI at baseline 30.8 ± 4.6 kg/m(2)). Biochemical and anthropometrical measurements were performed before and after 4 weeks of lifestyle interventions (comprising a reduction in energy intake to the age-matched optimum and a supervised exercise program consisting of 5 exercise units per day, 50 min each). RESULTS: The mean weight loss achieved was 6.2 ± 2.1 kg (P<0.001). Significant associations were found between a BMI decrease and the FTO and MC4R variants. Carriers of the FTO GG genotype and/or MC4R CC genotype lost significantly more body weight compared to noncarriers (P<0.0009 for BMI and P<0.002 for body weight). These differences remained significant following adjustment for sex, age and baseline values (P=0.004 for BMI and P=0.01 for body weight). CONCLUSIONS: FTO and MC4R gene variants modify the impact of an intensive lifestyle intervention on BMI decrease in overweight/obese children. Carriers of the FTO GG genotype and MC4R CC genotype benefit significantly more from the lifestyle intervention.
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