Glioblastoma multiforme (GBM) belongs to most aggressive and invasive primary brain tumor in adults whose prognosis and survival remains poor. Potential new treatment modalities include targeting the cytoskeleton. In our study, we demonstrated that repurposed drug flubendazole (FLU) significantly inhibits proliferation and survival of GBM cells. FLU exerted its effect by affecting microtubule structure and our results also suggest that FLU influences tubulins expression to a certain degree. Moreover, FLU effects decreased activation of STAT3 and also partially inhibited its expression, leading to upregulation of p53 signaling pathway and subsequent cell cycle arrest at G2/M phase as well as caspase-dependent cell death in GBM cells. These results suggest FLU as a promising agent to be used in GBM treatment and prompting further testing of its effects on GBM.

• MeSH
• apoptóza MeSH
• buněčný cyklus MeSH
• dospělí MeSH
• glioblastom * patologie   MeSH
• kontrolní body buněčného cyklu MeSH
• lidé MeSH
• mebendazol farmakologie   terapeutické užití   MeSH
• nádorové buněčné linie MeSH
• nádory mozku * patologie   MeSH
• proliferace buněk MeSH
• transkripční faktor STAT3 metabolismus   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• flubendazole MeSH Prohlížeč
• mebendazol MeSH
• STAT3 protein, human MeSH Prohlížeč
• transkripční faktor STAT3 MeSH