Nejvíce citovaný článek - PubMed ID 30003031
Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies: Associations with clinical severity, glucose metabolism and tau PET
We investigated whether cerebrovascular disease contributes to neurodegeneration and clinical phenotype in dementia with Lewy bodies (DLB). Regional cortical thickness and subcortical gray matter volumes were estimated from structural magnetic resonance imaging (MRI) in 165 DLB patients. Cortical and subcortical infarcts were recorded and white matter hyperintensities (WMHs) were assessed. Subcortical only infarcts were more frequent (13.3%) than cortical only infarcts (3.1%) or both subcortical and cortical infarcts (2.4%). Infarcts, irrespective of type, were associated with WMHs. A higher WMH volume was associated with thinner orbitofrontal, retrosplenial, and posterior cingulate cortices, smaller thalamus and pallidum, and larger caudate volume. A higher WMH volume was associated with the presence of visual hallucinations and lower global cognitive performance, and tended to be associated with the absence of probable rapid eye movement sleep behavior disorder. Presence of infarcts was associated with the absence of parkinsonism. We conclude that cerebrovascular disease is associated with gray matter neurodegeneration in patients with probable DLB, which may have implications for the multifactorial treatment of probable DLB.
- Klíčová slova
- Cerebrovascular disease, Dementia with Lewy bodies (DLB), Magnetic resonance imaging, Neurodegeneration, White matter hyperintensities, infarcts,
- MeSH
- bílá hmota diagnostické zobrazování patologie MeSH
- cerebrovaskulární poruchy komplikace MeSH
- degenerace nervu etiologie MeSH
- demence s Lewyho tělísky diagnostické zobrazování etiologie patologie psychologie MeSH
- halucinace MeSH
- kognice MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- mozková kůra krevní zásobení diagnostické zobrazování patologie MeSH
- mozkový infarkt diagnostické zobrazování patologie MeSH
- porucha chování v REM spánku etiologie MeSH
- šedá hmota diagnostické zobrazování patologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
