The aim of this study was to fabricate novel microparticles (MPs) for efficient and long-term delivery of amikacin (AMI). The emulsification method proposed for encapsulating AMI employed low-molecular-weight poly(lactic acid) (PLA) and poly(lactic acid-co-polyethylene glycol) (PLA-PEG), both supplemented with poly(vinyl alcohol) (PVA). The diameters of the particles obtained were determined as less than 30 μm. Based on an in-vitro release study, it was proven that the MPs (both PLA/PVA- and PLA-PEG/PVA-based) demonstrated long-term AMI release (2 months), the kinetics of which adhered to the Korsmeyer-Peppas model. The loading efficiencies of AMI in the study were determined at the followings levels: 36.5 ± 1.5 μg/mg for the PLA-based MPs and 106 ± 32 μg/mg for the PLA-PEG-based MPs. These values were relatively high and draw parallels with studies published on the encapsulation of aminoglycosides. The MPs provided antimicrobial action against the Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae bacterial strains. The materials were also comprehensively characterized by the following methods: differential scanning calorimetry; gel permeation chromatography; scanning electron microscopy; Fourier transform infrared spectroscopy-attenuated total reflectance; energy-dispersive X-ray fluorescence; and Brunauer-Emmett-Teller surface area analysis. The findings of this study contribute toward discerning new means for conducting targeted therapy with polar, broad spectrum antibiotics.

• Keywords
• amikacin encapsulation, drug delivery systems, microparticles, poly(lactic acid), targeted therapy,
• MeSH
• Amikacin administration & dosage   chemistry   MeSH
• Anti-Bacterial Agents administration & dosage   chemistry   MeSH
• Escherichia coli drug effects   MeSH
• Klebsiella pneumoniae drug effects   MeSH
• Lactates chemistry   MeSH
• Microbial Sensitivity Tests MeSH
• Molecular Weight MeSH
• Drug Carriers chemistry   MeSH
• Polyesters chemistry   MeSH
• Polyethylene Glycols chemistry   MeSH
• Polyvinyl Alcohol chemistry   MeSH
• Drug Compounding methods   MeSH
• Pseudomonas aeruginosa drug effects   MeSH
• Solubility MeSH
• Staphylococcus aureus drug effects   MeSH
• Capsules MeSH
• Drug Liberation MeSH
• Particle Size MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Amikacin MeSH
• Anti-Bacterial Agents MeSH
• Lactates MeSH
• Drug Carriers MeSH
• poly(lactic acid-ethylene glycol) MeSH Browser
• poly(lactide) MeSH Browser
• Polyesters MeSH
• Polyethylene Glycols MeSH
• Polyvinyl Alcohol MeSH
• Capsules MeSH