Acute myocardial infarction (AMI) is one of the leading causes of death among adults in older age. Understanding mechanisms how organism responds to ischemia is essential for the ischemic patient's prevention and treatment. Despite the great prevalence and incidence only a small number of studies utilize a metabolomic approach to describe AMI condition. Recent studies have shown the impact of metabolites on epigenetic changes, in these studies plasma metabolites were related to neurological outcome of the patients making metabolomic studies increasingly interesting. The aim of this study was to describe metabolomic response of an organism to ischemic stress through the changes in energetic metabolites and aminoacids in blood plasma in patients overcoming acute myocardial infarction. Blood plasma from patients in the first 12 h after onset of chest pain was collected and compared with volunteers without any history of ischemic diseases via NMR spectroscopy. Lowered plasma levels of pyruvate, alanine, glutamine and neurotransmitter precursors tyrosine and tryptophan were found. Further, we observed increased plasma levels of 3-hydroxybutyrate and acetoacetate in balance with decreased level of lipoproteins fraction, suggesting the ongoing ketonic state of an organism. Discriminatory analysis showed very promising performance where compounds: lipoproteins, alanine, pyruvate, glutamine, tryptophan and 3-hydroxybutyrate were of the highest discriminatory power with feasibility of successful statistical discrimination.

• MeSH
• Acetoacetates blood   MeSH
• Biomarkers blood   MeSH
• Chest Pain blood   physiopathology   MeSH
• Myocardial Infarction blood   diagnosis   MeSH
• 3-Hydroxybutyric Acid blood   MeSH
• Middle Aged MeSH
• Humans MeSH
• Lipoproteins blood   MeSH
• Magnetic Resonance Spectroscopy methods   MeSH
• Metabolome MeSH
• ROC Curve MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Acetoacetates MeSH
• acetoacetic acid MeSH Browser
• Biomarkers MeSH
• 3-Hydroxybutyric Acid MeSH
• Lipoproteins MeSH