(1) Background: This study evaluated the effects of a plant bioactive (Phyto Ax’Cell, Phytosynthese, Mozac, France) on the inflammatory status and health of dairy cows during calving. (2) Methods: 46 Holstein crossbred cows were randomized into a control group (CON, n = 23) and the Phyto Ax’Cell group (PAC, n = 23). PAC received Phyto Ax’Cell at 25 g/cow/day, from 15 days prepartum to 7 days postpartum. Blood analyses were performed weekly from D-7 to D14 to evaluate the energy metabolism and inflammatory status; rectal temperature was measured daily within 14 days from calving day (D0). (3) Results: PAC showed lower serum haptoglobin at D7 (0.55 vs. 0.79 mg/mL; p < 0.05) and D14 (0.44 vs. 0.66 mg/mL; p < 0.05). CON had a higher number of circulating white blood cells and granulocytes on D7 (p < 0.05). Fewer cows from PAC showed hyperthermia (≥39 °C) during the first 2 weeks postpartum (−7%, p < 0.05). Energy metabolism, which was represented by the NEFA/cholesterol ratio, improved (0.21 vs. 0.36 at D0, p < 0.1; 0.19 and 0.15 vs. 0.36 and 0.32, respectively, at D+7 and D+14, p < 0.05) under the plant bioactive supplementation. (4) Conclusions: The results suggest that the anti-inflammatory plant bioactive compound with Brazilian green propolis administered during calving had a beneficial effect on the energy and inflammatory status of dairy cows.

• Keywords
• energy status, inflammation, periparturient cows, plant bioactive compounds,
• MeSH
• Diet veterinary   MeSH
• Phytochemicals pharmacology   MeSH
• Haptoglobins metabolism   pharmacology   MeSH
• Fatty Acids, Nonesterified metabolism   MeSH
• Lactation MeSH
• Milk * metabolism   MeSH
• Dietary Supplements MeSH
• Propolis * pharmacology   MeSH
• Cattle MeSH
• Animals MeSH
• Check Tag
• Cattle MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Randomized Controlled Trial, Veterinary MeSH
• Names of Substances
• Phytochemicals MeSH
• Haptoglobins MeSH
• Fatty Acids, Nonesterified MeSH
• Propolis * MeSH