Age is a key risk factor associated with the severity of symptoms caused by SARS-CoV-2, and there is an urgent need to reduce COVID-19 morbidity and mortality in elderly individuals. We discuss evidence suggesting that trained immunity elicited by BCG vaccination may improve immune responses and can serve as a strategy to combat COVID-19 in this population.

• MeSH
• COVID-19 * MeSH
• Immunologic Memory MeSH
• Humans MeSH
• Immunity, Innate MeSH
• SARS-CoV-2 MeSH
• Aged MeSH
• Vaccination MeSH
• Check Tag
• Humans MeSH
• Aged MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

Recent data have revealed that fructose-rich diet triggers inflammation and lipid synthesis. Furthermore, lipid metabolism, cholesterol synthesis and sterol regulatory element binding protein-2 (SREBP-2) activation correlates with coronavirus disease 2019 (COVID-19)-induced cytokine storm. High fructose consumption result in SREBPs activation, altered cholesterol and lipid synthesis and may establish an innate immune memory in the cells, leading to severe COVID-19 in patients with obesity.

• Keywords
• COVID-19, cholesterol synthesis, cytokine storm, lipid synthesis, obesity,
• MeSH
• Cholesterol MeSH
• COVID-19 * MeSH
• Fructose MeSH
• Humans MeSH
• Lipogenesis * MeSH
• Sterol Regulatory Element Binding Protein 1 metabolism   MeSH
• CCAAT-Enhancer-Binding Proteins metabolism   MeSH
• SARS-CoV-2 MeSH
• Inflammation MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Comment MeSH
• Names of Substances
• Cholesterol MeSH
• Fructose MeSH
• Sterol Regulatory Element Binding Protein 1 MeSH
• CCAAT-Enhancer-Binding Proteins MeSH