Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, komentáře
PubMed
33455862
PubMed Central
PMC7833986
DOI
10.1016/j.tem.2021.01.001
PII: S1043-2760(21)00001-1
Knihovny.cz E-zdroje
- Klíčová slova
- COVID-19, cholesterol synthesis, cytokine storm, lipid synthesis, obesity,
- MeSH
- cholesterol MeSH
- COVID-19 * MeSH
- fruktosa MeSH
- lidé MeSH
- lipogeneze * MeSH
- protein SREBP1 metabolismus MeSH
- proteiny vázající zesilovač transkripce CCAAT metabolismus MeSH
- SARS-CoV-2 MeSH
- zánět MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- komentáře MeSH
- Názvy látek
- cholesterol MeSH
- fruktosa MeSH
- protein SREBP1 MeSH
- proteiny vázající zesilovač transkripce CCAAT MeSH
Recent data have revealed that fructose-rich diet triggers inflammation and lipid synthesis. Furthermore, lipid metabolism, cholesterol synthesis and sterol regulatory element binding protein-2 (SREBP-2) activation correlates with coronavirus disease 2019 (COVID-19)-induced cytokine storm. High fructose consumption result in SREBPs activation, altered cholesterol and lipid synthesis and may establish an innate immune memory in the cells, leading to severe COVID-19 in patients with obesity.
Zobrazit více v PubMed
Sohrabi S., et al. Trained immunity as a novel approach against COVID-19 with a focus on BCG vaccine: mechanisms, challenges and perspectives. Clin. Transl. Immunol. 2020;9 PubMed PMC
Todoric J., et al. Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat. Metab. 2020;2:1034–1045. PubMed PMC
Saltiel A.R., Olefsky J.M. Inflammatory mechanisms linking obesity and metabolic disease. J. Clin. Invest. 2017;127:1–4. PubMed PMC
Zhang D., et al. Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity. J. Clin. Invest. 2017;127:2855–2867. PubMed PMC
Sohrabi Y., et al. LXR activation induces a proinflammatory trained innate immunity-phenotype in human monocytes. Front. Immunol. 2020;11:353. PubMed PMC
Lee W., et al. COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm. Signal. Transduct. Target Ther. 2020;5:186. PubMed PMC
Guo C., et al. Cholesterol homeostatic regulator SCAP-SREBP2 integrates NLRP3 inflammasome activation and cholesterol biosynthetic signaling in macrophages. Immunity. 2018;49:842–856. PubMed
Li L.C., et al. Cross-talk between TLR4-MyD88-NF-kappaB and SCAP-SREBP2 pathways mediates macrophage foam cell formation. Am. J. Physiol. Heart Circ. Physiol. 2013;304:H874–H884. PubMed
Eid W., et al. mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 2017;114:7999–8004. PubMed PMC
Sohrabi Y., et al. Altered cellular metabolism drives trained immunity. Trends Endocrinol. Metab. 2018;29:602–605. PubMed
