Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (N = 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on suicidal behavior.

• Keywords
• Bipolar disorder, Major depression, Personality, Polygenic score, Schizophrenia, Suicidal behavior,
• MeSH
• Depressive Disorder, Major * psychology   MeSH
• Mental Health MeSH
• Phenotype MeSH
• Humans MeSH
• Personality genetics   MeSH
• Suicidal Ideation * MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH